B7 L8

Question 1

Hemoglobin

Answer 1

binds 4 O2- high affinity

reservoir for dissolved O2

Question 2

Adult Hemoglobin

Answer 2

2a + 2B chains

has heme molecule w/ iron

Question 3

Methemoglobin

Answer 3

no O2 affinity
result of some drugs
can be converted back by methemoglobin reductase

Question 4

Fetal Hemoglobin

Answer 4

2a and 2y chains

higher O2 affinity than A hemoglobin

Question 5

S Hemoglobin

Answer 5

mutation in B chain causes shape change- sickle cell

reduced O2 affinity

Question 6

SaO2

Answer 6

O2 saturation

100% in arterial, 75% in venous

Question 7

Myoglobin

Answer 7

1 O2 binding site
in muscle
store O2 delivered by hemoglobin

Question 8

Increasing Affinity

Answer 8

decrease P50
Easier to bind, harder to release
shift curve left

Question 9

Decreasing Affinity

Answer 9

Increase P50
Harder to bind, easier to release
shift curve right

Question 10

Alveoli at top of lungs

Answer 10

stretched more
reduced ventilation
low perfusion from compressed capillaries
higher resistance

Question 11

Alveoli at bottom of lungs

Answer 11

receive more blood flow but are compressed by capillaries