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Physiology > B8 L2 > Flashcards

B8 L2 Flashcards

1
Q

Hypothalamic Pituitary Adrenal Axis

HPA Axis

A

production of steroid hormones from adrenal cortex

and some male sex hormones

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2
Q

HPA Axis Format

A

Hypothalamus releases CRH
Ant pituitary releases ACTH
Adrenal cortex releases cortisol and aldosterone

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3
Q

HPA Axis Feedback

A

ACTH inhibits CRH

Cortisol inhibits ACTH and CRH

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4
Q

Cortisol

A

during fasting

maintain blood glucose, increase protein catabolism and fatty acid utilization, suppress immune system

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5
Q

Zona Glomerulosa

A

Adrenal cortex

makes aldosterone

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6
Q

Zona Fasciculate

A

Adrenal cortex

makes cortisol and androgens

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7
Q

Zona Reticularis

A

Adrenal cortex

makes cortisol and androgens

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8
Q

21B Hydroxylase Deficiency

A

loss of aldosterone and cortisol production

overproduction of androgens- virilization

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9
Q

Control Mineralocorticoids (Aldosterone)

A

RAAS

Blood K levels

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10
Q

Mineralocorticoids (Aldosterone) Mechanism

A

retain Na and water

secrete K

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11
Q

Cortisol Mechanisms

A

Stim gluconeogenesis by liver

anti-inflammatory and immunosuppression

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12
Q

Addison’s Disease

A

Primary Hypocortisolism-
adrenals dont make enough cortical hormones
hypoglycemia, weight loss, hypotension, hyperkalemia, acidosis, hyperpigmentation

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13
Q

Hyperpigmentation in Addison’s

A

from overproduction of ACTH- from same protein as MSH

MSH activates melanocytes

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14
Q

Cushing’s Syndrome

A

Primary Hypercortisolism
adrenals make too much cortisol
hyperglycemia and weight gain, hypertension, virilization
low aldosterone

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15
Q

Cushing’s Disease

A

Secondary Hypercortisolism

too much ACTH

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16
Q

Virilization in Cushing’s

A

from overflow of androgen production

17
Q

Conn Syndrome

A

Aldosterone secreting tumor

hypertension, hypokalemia, alkalosis

18
Q

Congenital Adrenal Hyperplasia

A

dysfunction in one of enzymes required for adrenal function

19
Q

17a Hydroxylase Deficiency

A

loss of cortisol and andrenal androgens

over production of aldosterone

Physiology (17 decks)

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