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2. Immunology > B Cell Activation > Flashcards

B Cell Activation Flashcards

1
Q

What happens when B cells are low?

A

Would lack or lose long lasting memory antibody

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2
Q

What do some clones of T cells do?

A

Become memory cells that remain in the body and can react swiftly if the same pathogen invades again

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3
Q

Membrane receptor for B cells

A

BCR (immunoglobulin) for antigen

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4
Q

B cell connections

A

Can connect to antigens right on the surface of the invading virus or bacteria

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5
Q

T cell connections

A

Can only connect to virus antigens on the outside of infected cell

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6
Q

B cell tissue distribution

A

Germinal centers of LNs, spleen, gut, respiratory tract, sub-scapular and medullary cords of LNs

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7
Q

T cell tissue distribution

A

Parafollicular areas of cortex in nodes, periarteriolar in spleen

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8
Q

What is the lifespan on B cells?

A

Short

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9
Q

What is the function of B cells

A

Humoral/ antibody mediated immune system (AMI)

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10
Q

How is the blood made up of B and T cells

A

20% B lymphocytes
80% T lymphocytes

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11
Q

What do B cells form?

A

Plasma cells and memory cells

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12
Q

T/F: plasma cells do not move to the site of infection

A

TRUE

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13
Q

Lymphoma in cats

A

Cancer of lymphocytes
Systemic disease
Increased chance if cat has feline leukemia and feline immunodeficiency virus

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14
Q

What are the common sites of lymphoma in cats?

A

Intestinal
Mediastinal
Renal

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15
Q

Intestinal Lymphoma

A

Most common in cats (50-70%)
9-13 years old
Mesenteric LN enlarged and GI tract infected

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16
Q

Mediastinal Lymphoma

A

Lymphoid organs in the chest infected
Seen in young cats (5 years old)
Strongly associated with Feline Leukemia Virus (80% of affected cats test positive

17
Q

Renal lymphoma

A

Lymphoma in the kidney leading to kidney failure
Associated with feline leukemia (50%)

18
Q

What are the signs of cats with lymphoma?

A

Enlargement of LNs, vomiting, diarrhea, loss of appetite, weight loss, fatigue, difficulty breathing, increased thirst/ urination
Redness, flakiness, ulcerations, itching or lumps in skin

19
Q

How do you diagnose lymphoma in cats?

A

Blood tests and biopsy of a lump/ enlarged LN

20
Q

How do you treat lymphoma in cats and dogs ?

A

Chemotherapy (hair loss doesn’t occur)

21
Q

Canine Lymphoma

A

Most common hematopoietic tumor affecting dogs
Diagnosed through PE and fine-needle aspirate cytology of enlarged LN

22
Q

How are most lymphoma’s in dogs classified?

A

Multicentric, large B cell tumors
Heterogenous disease

23
Q

Lymphoid Leukosis

A

Neoplastic disease of poultry caused by avian leukosis virus
B cell lymphoma that occurs @ 16 weeks of age and older

24
Q

How do you treat lymphoid leukosis

A

You can’t!
Eradication of virus from breeding flocks most effective

2. Immunology (24 decks)

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