B - 6. Indirect sympathomimetics. Selective a2-agonists and drugs acting on the imidazoline receptors

Question 1

Indirect Sympathomimetics classes

Answer 1

Psychostimulants (methamphetamine, amphetamine, MDMA)
- releases NE and dopamine
- significant a1 and b1 agonism
Ephedrines

Question 2

a1 agonists: names

Answer 2

Phenylephrine (selective)
oxymetazoline (non selective)

both used as nasal decongestants

Question 3

Indirect acting agonists drug names needed to know

Answer 3

Ephedrine

Question 4

Indirect Sympathomimetics basics

Answer 4

Drugs that potentiate endogenous catecholamines by either increasing their release or inhibiting their reuptake

Long duration of action
More regular pharmacological use than catecholamines

Question 5

Ephedrine

Answer 5

Releases monoamines
a and B receptor agonism
Used as nasal decongestants
- a1 vasoconstriction in mucosa

Question 6

Selective a1 agonists: function

Answer 6

a-1 agonism -> vasoconstriction

used as nasal decongestants and in septic shock as a vasoconstrictor

Question 7

α-2 agonists names

Answer 7

clonidine
rilmenidine
methyldopa

Question 8

α-2 agonists main effect

Answer 8

Antihypertensive effects