A - 8. Androgens, anabolic steroids, antiandrogens. Agents affecting the sexual activity

Question 1

Role of androgens and anabolic steroids

Answer 1

Androgens - male sexual features
Anabolic steroids - increase muscle mass

These are synthesized in a 1:1 ratio

Question 2

Androgen/anabolic drug names

Answer 2

testosterone-undecanoate

nandrolone

Question 3

Androgen/anabolic drug indications, contraindications and SE

Answer 3

Indications

• HRT
• HIV - increase muscle mass
• senile osteoporosis

SE:

• male sex characteristics
• hypertension
• decreased sperm production, shrinking of testicles

Contraindications

• pregnancy (virulization of fetus)
• cardiac/renal diseases
• prostate/breast cancer

Question 4

androgen receptor antagonists

Answer 4

bicalutamide

highly selectice comp. antagonist
used in prostate cancer

Question 5

5-a reductace inhibitors

Answer 5

finasteride

Hair loss, prostatic hyperplasia

Question 6

testosterone synthesis inhibitors

Answer 6

gosereline

GnRH analogue, causes initial increase in sex hormones followed by a huge down regulation of receptors

IND: breast and prostate cancer

Question 7

GnRH antagonists

Answer 7

degarelix

Blocks LH/FSH release
Supresses testosterone production -> prostate cancer indication

Question 8

Viagra

Answer 8

Sildenafil

Selective PDE5 inhibitor, cGMP spared -> vasodialation