A - 10. Progestins and antiprogestins Flashcards
1
Q
Progresterone actions
A
- maintain pregnancy
- secretory phase - maturing glands
- decreases motility of fallopian tubes and uterus
- hostile to sperm
- acini proliferation increased
- glucose intolerance
- LDL up
- fat deposition (LPL upregulated)
- water retention -> edema
- increases testosterone
- decrease estrogen synthesis
2
Q
Use of progestins
A
- contraception in combination with or without estrogen
- dysfunctional uterine bleeding
- endometriosis (inhibition of ovulation -> no proliferation of uterus)
- HRT
- endometrial carcinoma
- postpone menstrual cycle
3
Q
Side effects of progestins
A
- acne
- edema
- weight gain
- depression
- hirsutism
- breast cancer
4
Q
Synhetic progesterone derivatives
A
medroxyprogesterone-acetate
drospirenone
5
Q
Synthetic non-progesterone derivatives
A
norethisteron
levonorgestrel
desogestrel
6
Q
Antiprogestins - names
A
cyproteron-acetate
mifepristone
ulipristal acetate
7
Q
Antiprogestins - use/SE
A
Used for
- abortions
- emergency contraceptive
SE:
- bleeding
- nausea
- pain
- headaches
