autoimmune dx Flashcards

1
Q

rheumatoid arthritis (RA)

A
  • chronic, systemic autoimmune dz
  • inflammation of connective tissue in the synovial joints
  • periods of remission and exacerbation
  • can occur at any time, incidence increases with age
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2
Q

causes of RA

A
  • autoimmune
  • *genetics
  • smoking
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3
Q

diagnosing RA

A
  • H/P
  • +rheumatoid factor
  • ESR and CRP=active inflammation
  • xray: for later disease
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4
Q

RA classification criteria

A
  • morning stiffness that lasts at least an hour
  • polyarthritis
  • arthritis in the wrist, or finger joints
  • symmetrical arthritis
  • positive rheumatoid factor
  • radiological abnormalities of hands or wrist
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5
Q

nonspecific s/s of RA

A
  • fatigue
  • anorexia
  • wt loss
  • generalized stiffness
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6
Q

specific articular s/s of RA

A
  • pain
  • stiffness
  • limited motion
  • s/s inflammation
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7
Q

extraarticular s/s of RA

A
  • rheumatoid nodules
  • Sjogren’s syndrome
  • Felty syndrome
  • pleural effusion, pericarditis, pericardial effusion, cardiomyopathy
  • cataracts
  • depression
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8
Q

rheumatoid nodules

A

firm, non tender granuloma type masses locate over joints

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9
Q

Sjogren’s syndrome

A
  • diminished lacrimal and salivary gland secretion

- photosensitivity

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10
Q

Felty syndrome

A
  • splenomegaly

- leukopenia

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11
Q

tx for Sjogren’s syndrome

A
  • goal: to relieve symptoms
  • dry eyes: artificial tears, eye lubricating ointments, or cyclosporine liquid
  • dry mouth: H2O, chewing sugarless gum
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12
Q

tx for RA

A
  • rest
  • joint protection
  • heat/cold application
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13
Q

systemic lupus erythematosus (SLE)

A
  • multisystem inflammatory autoimmune dz
  • chronic, unpredictable course
  • periods of exacerbation and remission
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14
Q

causes of SLE

A
  • **unknown
  • genetics
  • hormones
  • environment: sun exposure, infx
  • drug reactions
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15
Q

diagnosing SLE

A
  • ANA, anti ENA
  • complement system levels
  • electrolytes
  • renal function
  • liver enzymes
  • CBC
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16
Q

diagnosing SLE

A
  • SOAP BRAIN MD
  • serositis
  • oral ulcers
  • arthritis
  • photosensitivity
  • blood dx
  • renal dx
  • antinuclear antibody test positive
  • immunological dx
  • neurological dx
  • malar rash
  • discoid rash
17
Q

general s/s of SLE

A
  • fever
  • malaise
  • joint pains
  • myalgias
  • fatigue
  • temp loss of cognitive abilities
18
Q

dermatological s/s of SLE

A
  • cutaneous vascular lesions
  • butterfly rash over cheeks
  • oral/nasopharyngeal lesions
  • alopecia
19
Q

musculoskeletal s/s of SLE

A
  • arthritis
  • polyarthralgia with morning stiffness
  • swelling
  • increased risk for bone loss and fx
20
Q

cardiopulmonary s/s of SLE

A
  • increased RR
  • cough
  • dysrhythmias
  • HTN
  • increased cholesterol
  • increased risk for clots
21
Q

renal s/s of SLE

A
  • lupus nephritis
  • proteinuria
  • ESRD
22
Q

nervous system s/s of SLE

A
  • sz
  • peripheral neuropathy
  • cognitive dysfunction
  • depression
  • psychosis
  • HA
23
Q

hematological s/s of SLE

A
  • anemia
  • mild leukopenia
  • thrombocytopenia
  • excessive bleeding
  • clot formation
24
Q

infection in SLE

A
  • increased susceptibility to infx
  • major cause of death
  • avoid live virus vaccines
25
Q

tx of SLE

A
  • NSAIDs, antimalarials
  • disease modifying anti rheumatic drugs
  • immunosuppresants
  • analgesics
  • lifestyle changes
  • renal transplant
26
Q

good prognosis for SLE

A
  • early dx
  • prompt recognition of organ involvement
  • good therapeutic regimens
27
Q

fibromyalgia

A
  • widespread, non articular musculoskeletal pain and fatigue

- multiple tender points

28
Q

etiology of fibromyalgia

A
  • genetics
  • stress
  • central dopamine dysfunction
  • abnormal serotonin metabolism
  • deficient human growth hormone
29
Q

tender points

A
  • palpation elicits pain
  • not all at a time
  • can change points throughout the day
30
Q

s/s of fibromyalgia

A
  • burning, widespread pain
  • fatigue
  • tingling of the skin
  • prolonged muscle spasms
  • weak limbs
  • nerve pain
  • TMJ pain
31
Q

gout

A
  • type of recurring acute arthritis

- accumulation of uric acid crystals in one or more joints

32
Q

causes of gout

A
  • increase in urban acid production
  • underexcretion of uric acid
  • high purine diet will trigger
33
Q

high purine foods

A
  • shellfish
  • lentils
  • asparagus
  • spinach
  • meats
34
Q

diagnosing gout

A
  • serum uric acid level above 6mg/dL
  • 24 hour urine: decreased renal excretion vs overproduction
  • synovial fluid aspiration
35
Q

s/s of acute phase gout

A
  • arthritis in one or more joints
  • joints are dusky or cyanotic
  • tenderness
  • podagra (inflamed great toe)
36
Q

s/s of chronic phase gout

A
  • multiple joint involvement
  • tophi
  • kidney/urinary tract stones
37
Q

collaborative care of gout

A
  • terminate acute attack: colchicine
  • prevent future attacks
  • diet and weight reduction: avoid etoh and purine
  • meds