Autoantibody

Question 1

Anti-glutamic acid decarboxylase antibodies (anti-GAD)

Answer 1

stiff-person syndrome
diabetes

Question 2

N-methyl-D-aspartate receptor (NMDAR) antibodies

Answer 2

autoimmune enchephalitis

Question 3

contactin-associated protein-like (Caspr2) antibodies

Answer 3

autoimmune enchephalitis
autoimmune epilepsy

Question 4

anti-yo antibodies

Answer 4

paraneoplastic cerebellar degeneration

Question 5

anti-p155

Answer 5

dermatomyositis
also associated wth cancer of stomach, breast, gallbladder

Question 6

anti-Jo1

Answer 6

inflammatory myopathy

Question 7

anti-SRP

Answer 7

polymyositis

Question 8

anti-smith

Answer 8

SLE

Question 9

anti-aquaporin 4 (NMO-IgG) antibodies

Answer 9

neuromyelitis optica spectrum disorder

can also be seen in classic MS

Question 10

anti-LGL1

Answer 10

limbic encephalitis
faciobracial seizures + MRI changes, memory loss, behavioural changes

Question 11

anti-NMDA

Answer 11

anti-NMDA receptor enchepalitis
often fever, headache, tired
can be triggered by HSV
presence of IgG

Question 12

AChR antibodies

Answer 12

myasthenia graves
85%

Question 13

MuSK antibodies

Answer 13

myasthenia graves
8%
more bulbar than systemic

Question 14

anti-histone

Answer 14

drug induced SLE

Question 15

U1RNP antibody

Answer 15

mixed connective tissue disease

Question 16

Anti-MDA-5

Answer 16

dermatomyositis + rapidly progressive lung disease

Question 17

Anti-Mi-2

Answer 17

dermatomyositis + severe muscle disease

Question 18

Anti-NXP-2

Answer 18

young onset dermatomyositis, or disease associated with malignancy in adults

Question 19

Anti-HMGCR

Answer 19

immune-mediated necrotising myopathy
associated in 50% of cases with statin use

Question 20

anti-mitochondrial antibodies

Answer 20

primary biliary cirrhosis