Autoantibody Flashcards

1
Q

Anti-glutamic acid decarboxylase antibodies (anti-GAD)

A

stiff-person syndrome
diabetes

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2
Q

N-methyl-D-aspartate receptor (NMDAR) antibodies

A

autoimmune enchephalitis

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3
Q

contactin-associated protein-like (Caspr2) antibodies

A

autoimmune enchephalitis
autoimmune epilepsy

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4
Q

anti-yo antibodies

A

paraneoplastic cerebellar degeneration

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5
Q

anti-p155

A

dermatomyositis
also associated wth cancer of stomach, breast, gallbladder

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6
Q

anti-Jo1

A

inflammatory myopathy

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7
Q

anti-SRP

A

polymyositis

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8
Q

anti-smith

A

SLE

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9
Q

anti-aquaporin 4 (NMO-IgG) antibodies

A

neuromyelitis optica spectrum disorder

can also be seen in classic MS

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10
Q

anti-LGL1

A

limbic encephalitis
faciobracial seizures + MRI changes, memory loss, behavioural changes

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11
Q

anti-NMDA

A

anti-NMDA receptor enchepalitis
often fever, headache, tired
can be triggered by HSV
presence of IgG

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12
Q

AChR antibodies

A

myasthenia graves
85%

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13
Q

MuSK antibodies

A

myasthenia graves
8%
more bulbar than systemic

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14
Q

anti-histone

A

drug induced SLE

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15
Q

U1RNP antibody

A

mixed connective tissue disease

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16
Q

Anti-MDA-5

A

dermatomyositis + rapidly progressive lung disease

17
Q

Anti-Mi-2

A

dermatomyositis + severe muscle disease

18
Q

Anti-NXP-2

A

young onset dermatomyositis, or disease associated with malignancy in adults

19
Q

Anti-HMGCR

A

immune-mediated necrotising myopathy
associated in 50% of cases with statin use

20
Q

anti-mitochondrial antibodies

A

primary biliary cirrhosis