HIV Drugs

Question 1

List the NRTIs

Answer 1

Abacavir, lamivudine, emtricitabine, zidovudine

Question 2

List the nucleotide reverse transcriptase inhibitor

Answer 2

tenofovir

Question 3

What is a major toxicity of tenofovir?

Answer 3

Renal toxicity- actively transported to the proximal renal tubular cells

can also cause osteopenia/osteoporosis

Question 4

What special testing do we need to do for abacavir?

Answer 4

HLA-B*5701- indication of developing abacavir hypersensitivity syndrome

Question 5

List the non-nucleoside reverse transcriptase inhibitors

Answer 5

nevirapine (NVP)
efavirenz (EFV)
rilpivirine (RPV)
etravirine (ETR)
doravirine (DOR)

Question 6

Which NNRTI gives you neuropsychiatric symptoms

Answer 6

efavirenz

Question 7

S/E of zidovudine

Answer 7

bone marrow suppression

Question 8

What is the major side effect of atazanavir

Answer 8

prolonged PR

stones (cholelithiasis, nephrolithiasis), benign unconjugated
hyperbilirubinemia.

NOT associated with metabolic syndrome

Question 9

List protease inhibitors

Answer 9

Atazanavir
Darunavir
fosamprenavir

Question 10

List the integrase inhibitors

Answer 10

dolutegravir
raltegravir
bictegravir