RACP-MedOnc Flashcards
What is the most common form of thyroid cancer?
a) Medullary
b) Follicular
c) Papillary
d) Anaplastic
e) Squamous Cell
C- Papillary
In patients with Breast Cancer, bone metastases are more likely to occur in which subgroup?
a) ER positive
b) PR positive
c) HER 2 overexpressed
d) Triple negative
e) BRCA1 mutation positive
a) ER positive
Which is the most common form of lung cancer in Australia?
a) Squamous
b) Adenocarcinoma
c) Small cell
d) Large cell
e) Bronchoalveolar
b) Adenocarcinoma
. Treatment of oestrogen-receptor positive breast cancer with tamoxifen causes cells to
accumulate in which cell cycle phase?
A. G0
B. G1
C. G2
D. M
E. S
B) G1
A 60 year old man with a history of prostate cancer treated with radiotherapy, presents with rectal bleeding causing hypotension requiring blood transfusion.
After initial resuscitation, continued bleeding would be best managed by which of the following measures?
A) Colonoscopic argon thermal coagulation
B) Radiological embolization
C) Surgical resection
D) Oral tranexamic acid
E) IV vasopressin
A- Colonoscopic argon thermal coagulation
first line for radiation proctitis induced bleeding
What is the mechanism for increased efficacy of Trastuzumab-Emtansine (T-DM1)?
A. Increased half-life
B. Decreased efflux
C. Targeted delivery
D. Antibody dependent cell-mediated cytoxicity
C. Targeted delivery
Mechanism of action of abiraterone in castrate resistant prostate ca?
A. Inhibits demineralisation of androgen receptor in prostate
B. Inhibits LH action on prostate
C. Inhibits conversion of dihydrotestosterone from testosterone
D. Inhibits conversion of testosterone from oestrogen
E. Inhibits testosterone production from prostate cancer cells
E. Inhibits testosterone production from prostate cancer cells
Squamous cell carcinoma is most common with which immunosuppressive agent?
A. Mycophenolate mofetil
B. Methotrexate
C. Azathioprine
D. Leflunomide
C. Azathioprine
What is the most common type of cancer associated with primary immunodeficiencies?
A. Melanoma
B. Sarcoma
C. Lymphoma
D. Carcinoma
C. Lymphoma
Patient with non-Hodgkin’s lymphoma receiving R-CHOP. Which agent carries the highest risk of peripheral neuropathy?
A. Rituximab
B. Cyclophosphamide
C. Doxorubicin
D. Vincristine
D. Vincristine
A 72yo male with Burkitt’s lymphoma is to commence on chemotherapy. There is evidence of tumour lysis syndrome prior to commencement of therapy. What is the most appropriate method to reduce the risk of tumour lysis syndrome?
A. Intravenous fluids
B. Rasburicase
C. Frusemide
D. Allopurinol
B- Rasburicase
Rasburicase: Breaks down uric acid into allantoin (more soluble) for rapid uric acid reduction. Used in established or high-risk tumor lysis syndrome.
Allopurinol: Inhibits xanthine oxidase to prevent uric acid formation. Used for prevention, less effective if uric acid is already high.
- What is the mechanism for somatic chromosomal translocation as causing cancer?
A) Gene Fusion
B) Non homolygous end joining
C) Haplotype
A) Gene Fusion
Translocations observed in cancer may inactivate tumour suppressor genes or activate oncogenes by (1) gene fusion or (2) juxtaposition of a strong promoter with a proto-oncogene.
- What form of thyroid cancer has the worst prognosis
A) Anaplastic
B) Papillary
C) Follicular
D) Medullary
A) Anaplastic
- What pathway does PARP inhibitors act on?
A) Base excision repair
B) Double stranded repair recombinase pathway
C) Nucleotide Excision repair
D) CDK4/6
A) Base excision repair
but note that BRCA mutations affect the double started repair pathway
- Mammography typically underestimates the size of which type of breast cancer?
A) Lobular
B) Ductal
C) Mucinous
A) Lobular
