2024 trial 1

Question 1

Which of the following hormones does NOT stimulate food intake?
A. Agouti-related peptide
B. Neuropeptide Y
C. Oxyntomodulin
D. Ghrelin

Answer 1

C- oxyntomodulin

Question 2

CYP- inducers, inhibitors, substrate

Answer 2

Inducers COPS
- Carbamazepine
- Oxcarbazepine
- Phenytoin/phenobarbital
- Smoking/St John’s wort

Inhibitors SICKFACES.com
- Sodium valproate
- Isoniazid
- cimetidine
- ketoconazole
- fluconazole
- alcohol
- chloramphenicol
- erythromycin
- sulphonamides
- ciprofloxacin
- omeprazole
- metronidazole
- disulfiram

substrate – WAR Against THe OCPs
- warfarin
- anti-epileptics + clozapine
- theophylline
- OCPs

Question 3

What is the mechanism of action of Mavacamten?

Answer 3

Modulation of cardiac actin-myosin interaction

Question 4

What is the mechanism of action of ranolazine

Answer 4

Inhibition of late inward sodium current (INa) channels

Question 5

what is the MOA of sclerostin?

Answer 5

inhibit bone formation by osteoblasts

Question 6

hepatocyte ballooning

Answer 6

non-alcoholic fatty liver disease (NAFLD)

Question 7

mallory denk bodies

Answer 7

alcoholic liver disease
can be seen in NASH

Question 8

what is the inheritance pattern of Huntington disease

Answer 8

autosomal dominant

Question 9

what is the inheritance pattern of cystic fibrosis

Answer 9

autosomal recessive

Question 10

what is the inheritance pattern of marfans syndrome?

Answer 10

autosomal dominant

Question 11

what is the inheritance pattern of Achondroplasia

Answer 11

autosomal dominant

Question 12

tear drop cells

Answer 12

myelofibrosis

Question 13

What is cKIT D816V associated with?

Answer 13

systemic mastocytosis

Question 14

What molecular abnormalities are found in myelofibrosis?

Answer 14

JAK2 V617F mutation
Type 1 Calreticulin mutation

Question 15

Mutations of which gene are the MOST common cause of autosomal dominant polycystic kidney disease?

A. PKHD1
B. COL4A3
C. COL4A4
D. Polycystin-1

Answer 15

Answer: D polycystin-1

PKHD1 is affected in autosomal recessive PKD, and the COL4A genes are affected in Alport Syndrome.

Question 16

What is Vitamin B1 deficiency seen in?

Answer 16

ie Thiamine
Wernicke’s encephalopathy

Question 17

What is Vitamin B6 deficiency?

Answer 17

Pyridoxine deficiency
would lead to peripheral neuropath

Question 18

What is Vitamin B9

Answer 18

folate

Question 19

What is the triad for lambert eaton syndrome

Answer 19

proximal weakness, areflexia, and autonomic dysfunction.

Question 20

Describe the surveillance of patients for hepatocellular cancer in chronic hep B infection

Answer 20

Question 21

What is Staphylococcus pseudintermedius associated with?

Answer 21

Staph aureus-like infections in dogs

Question 22

What is Burkholderia cepacia a cause of?

Answer 22

A cause of respiratory infection in patients with cystic fibrosis

Question 23

What is Capnocytophaga canimorsus a cause of?

Answer 23

severe sepsis and DIC in patients after dog bites or sometimes even lesser canine exposures

Question 24

What is Bartonella henselae?

Answer 24

a cause of cat scratch disease

Question 25

In patients with acute myocardial infarction complicated by cardiogenic shock who are treated with an early invasive strategy with percutaneous coronary intervention of the infarct-related artery, mortality can be reduced by: A. Routine use of an intra-aortic balloon pump B. Using full circulatory support with extracorporeal life support (ECMO) C. Performing PCI to lesions in the non-culprit arteries during the index procedure to achieve complete revascularisation D. Using a microaxial transvalvular flow pump (Impella)

Answer 25

Correct Answer: D Using a microaxial transvalvular flow pump (Impella)

Question 26

what is a classic case of Q fever

Answer 26

fever, pneumonia, and hepatitis The occupational exposure (abattoir work) is strongly linked to this disease.

Question 27

What is Chlamydophila psittaci?

Answer 27

a cause of atypical pneumonia with exposure to birds

Question 28

What is Burkholderia pseudomallei

Answer 28

Burkholderia pseudomallei (Melioid) is a cause of tropical pneumonia mostly in the Northern territory and Queensland

Question 29

What part of the LFTs does copper interfere with?

Answer 29

ALP

Question 30

Describe the cranial nerves location- rule of fours

Answer 30

Above the pons: 1-4 Pons: 5-8 Medulla: 9-12

Question 31

Describe the JVP curve

Answer 31

Question 32

What is the pharm management of serotonin syndrome?

Answer 32

Serotonin antagonist: - cyproheptadine

Question 32

What is the pharm management of neuroleptic malignant syndrome?

Answer 32

Dantrolene Bromocriptine (dopamine agonist) Amantadine (dopamine agonist)

Question 32

What is the pharm management of anti-cholinergic syndrome?

Answer 32

Physotigmine (pro-cholinergic agent) Activated charcoal

Question 33

What is the pharm management of cholinergic syndrome?

Answer 33

Atropine and pralidoxime