Chromosomal translocation Flashcards
1
Q
t(8;21) (RUNX1-RUNx1t1)
A
AML, specifically AML with maturation
Good prognosis
2
Q
t(16;16)
A
AML, particularly acute myelomonocytic leukemia
3
Q
t(9;22)
A
philadelphia chromosome
CML
4
Q
t(12;21)
A
ALL, specifically in paediatric patients
5
Q
t(8;14)
A
Burkett lymphoma
6
Q
t(5;14)
A
ALL, particularly eosinophilia-associated ALL
7
Q
t(1;19)
A
ALL, especially pre-B cell ALL
8
Q
t(14;18)
A
follicular lymphoma
9
Q
t(15;17)
A
APML. good prognosis
10
Q
t(1;22)
A
AMKL (acute megakaryoblastic leukaemia) -particularly infants
11
Q
Which of the following genetic mutations/translocations is associated with a poor prognosis in acute myeloid leukaemia?
A. NPM1
B. PML-RARa
C. RUNX1-RUNX1T1
D. ASXL1
A
ASXL1
Mutations occur in exon 12 and cause truncation of the protein product.
