Arteriviruses Flashcards
Arterivirus, the virulence is highly variable
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The equine viral arteritis is caused by an arterivirus.
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Serological tests can NOT be used for laboratory detection of equine viral arteritis
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- Serology: VN (1:4), ELISA (gp5)
ed blood cells can be used for laboratory detection of equine viral arteritis virus
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Samples: nasal fluid, WBC, semen, caul
Nasal fluid can be used for laboratory detection of equine viral arteritis virus
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A semen sample can be used for laboratory detection of equine viral arteritis virus
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Equine arteritis virus is very resistant to physical damages
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Low resistance in environment
Equine viral arteritis is usually asymptomatic
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In cases of equine viral arteritis, the rate of seroconverted animals increases with age
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The main target cells of equine viral arteritis are macrophage
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Replication: Macrophages, endothelialcells, vascular smooth muscle cells
Equine Viral arteritis (EVA) virus can affect donkeys
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horses, ponies, donkeys and zebras (South american Camelids)
The persistence of EVA virus within one herd is usually caused by the stallions
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persistent infection in mature animals
EVA is transmitted by sexual and aerogenic pathways
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sexual transmission: 1 week
After EVA virus infection, mortality rate is low
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Equine arteritis virus is very resistant to physical damage
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Low resistance in environment
Equine viral arteritis is usually asymptomatic
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The main target cells of equine viral arteritis virus are macrophages
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EVA can affect donkeys
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horses, ponies, donkeys and zebras
EVA can cause persistent virus carrying.
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persistent infection in mature animals
After EVA infection mortality rate is low
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Equine Viral Arteritis virus can infect by inhalation
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Vaccine against Equine Viral Arteritis is never used in Europe
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Inactivated (in EU) 2X
The Equine Viral Arteritis is caused by retrovirus
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Arteriviridae Family
The equine viral arteritis virus cannot damage the wall of blood vessel
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Damage of blood vessel walls (inflammation in the endothel and media)
The equine viral arteritis virus usually causes asymptomatic infection
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The equine viral arteritis virus can cause persistent infections
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persistent infection in mature animals
The equine viral arteritis virus always causes clinical symptoms
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- usually asymptomatic
EVA is spread by insect vectors
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venereal, nasal (per os)
Equine viral arteritis causes reproductive problems/impotence in stallions.
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Acute equine viral arteritis is similar to Equine infectious anaemia
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Equine viral arteritis in mare is reactivated in pregnancy
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Equine viral arteritis, aborted embryos have degenerated liver
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- Fibrinoid degeneration
- inflammation and thrombus formation in small blood vessels
- Interlobular interstitial pneumonia
- Fibrinoid-necrotic enteritis
Mares are frequently life-long carriers of the Equine arteritis virus.
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Stallions: long term carriers (10-70%)
Subcutaneous oedema is a frequent sign of equine viral arteritis
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Pregnant mares usually abort in the acute phase of equine viral arteritis
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Equine viral arteritis is diagnosed by agarose-gel immunodiffusion (Coggins test)
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- Clinical signs, pathology
- Samples: nasal fluid, WBC, semen, caul
- Isolation (CPE), IF, IHC, RT-PCR (semen)
- Serology: VN (1:4), ELISA (gp5)
The Equine arteritis virus may cause abortion in pregnant mares
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Vaccination of colts before puberty can prevent the development of EAV-carrier status
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Stallions may be long-term carriers of the Equine arteritis virus
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Stallions: long term carriers (10-70%), semen (for years),
Conjunctivitis and subcutaneous oedema are possible signs of equine viral arteritis.
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Equine viral arteritis virus can infect through nasal route
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Equine viral arteritis virus can infect per os
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