AP propagation

Question 1

Three states of Na+ channel

Answer 1

• Resting, activated, inactivated
• Inactivated means channel is open but inactivation gate is closed so it is blocking it

Question 2

Two states of K+ channels

Answer 2

• Resting, activated

Question 3

True/False - The channels sitting on the membrane open all at once

Answer 3

False

Question 4

How do Local anesthetics work?

Answer 4

• Block the Na channels so that depolarization and AP propagation cannot occur
• leads to temporary loss of function
• usually unionized compounds but can be ionized
• DO NOT LEAD TO HYPERPOLARIZATION