Antiviral Treatment Strategies- Exam IV Flashcards
Antiviral treatment strategies/targets include:
- inhibitors of viral replication
- virus entry
- viral genome replication
- viral release
Every step in ___ is a potential target for antiviral treatment
viral replication
Targeting ___ is generally not a feasible antiviral treatment strategy:
host cell functions
Why is targeting host cell function generally not feasible?
due to toxicity
What type of antiviral drugs act on the penetration step?
Enfuvirtide and fusion inhibitors
What type of antiviral drugs act after penetration and before uncoating?
Rimantadine & Amantadine
What type of antiviral drugs act on the genome replication step?
- Acyclovir
- Ganciclovir
- Foscarnet
- HIV reverse transcriptase inhibitors
What type of antiviral drugs act after genome replication but before RNA synthesis?
- Ribavirin and Interferon
What type of antiviral drugs after RNA synthesis and before protein synthesis?
Interferon
What type of antiviral drugs act after assembly but before release?
neuraminidase inhibitors
HIV fusion inhibitor that binds to gp41 region that folds back onto itself and prevent fusion of membranes (very specific to HIV)
Enfuvirtide
Enfuvirtide is a ___ fusion inhibitor:
HIV fusion inhibitor
Enfuvirtide binds to ___ region that folds back onto itself and prevents ____
gp41; fusion of membranes
CCR5 binding inhibitor =
maraviroc
What step do both enfuvirtide and maraviroc work at?
virus entry
This step in viral infection is used to prevent influenza infections and blocks penetration and uncoating of influenza A virus:
virus entry
The drug used to prevent influenza entry and blocks penetration and uncoating of influenza A virus (basically blocks virus entry):
amantadine
Analog of Amantadine:
Rimantadine
Amantadine and Rimantadine affect:
M2’s function as an ion channel
How does manta dine and rimantadine affect M2’s function as an ion channel?
following endocytosis, acidification of endosomes occur, and then M2 can function as ion channel and the acidification within virion drives the viral disassembly
Following endocytosis acidification of ____ occurs, then ___ can function as an ion channel
endosomes; M2
Acidification within virions drives:
viral disassembly
Monoclonal antibodies (mAb’s) against SARS Coverage-2 are:
viral entry inhibitors
What is one treatment option for Covid-19?
Monoclonal antibodies