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HISTOPATH > ANTIGEN TUMOR MARKERS > Flashcards

ANTIGEN TUMOR MARKERS Flashcards

1
Q

marker of epithelial cells

A

keratin

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2
Q

marker of carcinomas of lung, breasts, uterus, ovarian cancers

A

CK7 (+)

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3
Q

colon and stomach cancers

A

CK20 (+)

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4
Q

transitional cell carcinomas of bladder and mucinous ovarian tumors

A

CK7 and CK20 (+)

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5
Q

renal cell carcinomas, liver carcinomas, prostatic adenocarcinomas, thyroid and squamous cell carcinomas

A

CK7 and CK20 neg

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6
Q

helpful in determining the site of tumor; (+) for breast adenocarcinomas, lungs, and kidneys

A

EMA (Epithelial Membrane Antigen)

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7
Q

an oncofetal antigen present carcinomas of GI tract, pancreas, lung, breast, ovary, uterus, cervix

A

CEA (Carcinoembryonic Antigen)

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8
Q

DIFFERENTIATES adenocarcinoma (+) from mesothelioma (-)

A

CEA (Carcinoembryonic Antigen)

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9
Q

DISTINGUISHES lung adenocarcinoma from mesothelioma

A

TTF-1 (Thyroid Transcription factor 1)

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10
Q

present in thyroid gland neoplasms

A

TTF-1 (Thyroid Transcription Factor 1)

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11
Q

(+) Prostate Adenocarcinoma, pancreatic, and salivary tumors

A

PSA (Prostatic Specific Antigen)

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12
Q

normally found in breast epithelial cells but not myoepithelial cells

A

ER/PR (Estrogen/Progesterone Receptor)

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13
Q

Prognosis and treatment of breast CA

A

ER/PR (Estrogen/Progesterone Receptor

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14
Q

identification of metastatic breast CA

A

ER/PR (Estrogen/Progesterone Receptor)

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15
Q

sensitive marker for muscle differentiation

A

actin

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16
Q

identify tumors derived from smooth, skeletal, and cardiac muscles

A

actin

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17
Q

normally present in mesenchymal cells and neoplastic cells such as sarcomas, lymphomas, leukemias, seminomas, neural tumors

A

vimentin

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18
Q

always stain positive in vimentin

A

melanomas and schwannomas

19
Q

desmin is highly specific for

A

myogenic tumors

20
Q

normally expressed by CNS glial cells especially as

A

GFAP (glial fibrillary acidic protein)

21
Q

diagnosis of astrocytoma

A

GFAP (glial fibrillary acidic protein)

22
Q

expressed by cells of neural origin; (+) in neuroblastomas, ganglioneuromonas, neuromas, chemodectomas

A

neurofilament

23
Q

expressed by CNS glial cells, schwann cells, melanocytes, histiocytes, chrondrocytes, skeletal and cardiac muscles, myoepithelial cells, epithelial cells of the breast, salivary and sweat glands

A

S100 Protein (calcium binding protein)

24
Q

(+) for tumors with neural or neuroendocrine differentiation

A

NSE(Neuron specific enolase)

25
Q

found in neural secretory granules of endocrine tissues

A

chromogranin

26
Q

(+) neuroendocrine differentiation

A

chromogranin

27
Q

keratin (+), chromogranin (+)

A

neuroendocrine carcinomas

28
Q

present in presynaptic vesicles of neurons, normal neurons, and neuroendocrine cells

A

synaptophysin

29
Q

HCG is synthesized by placental ________

A

synctiotrophoblast

30
Q

(+) germ cell tumors/choriocarcinoma

A

HCG (Human Chorionic Gonadotropin)

31
Q

synthesized by normal liver; (+) hepatocellular CA

A

Alpha-fetoprotein (AFP)

32
Q

produced by placental syncytiotrophoblasts in late pregnancy

A

Placental-like Alkaline Antigen (PLAP)

33
Q

(+) germ cell tumors, embryonal CA, chorioCA, Endodermal sinus tumor, seminoma

A

Placental-like Alkaline Antigen (PLAP)

34
Q

tumors of skeletal muscle origin

A

myogenic tumors

35
Q

(+) Actin, Desmin, Myo D-1, Myoglobin, Myogenin

A

Myogenic tumors

36
Q

(+) CD68, FAM 56, Alpha-1 Antitrypsin, Alpha-1 Antichymotrypsin; Malignant Fibrohistiosarcoma

A

Fibrohistiocytic tumors

37
Q

(+) factor VII- related antigen, CD31, Ulex Europaeus (UEA); endothelial markers; angiosarcoma

A

vascular tumors

38
Q

(+) S100 protein

A

melanocytes are derived from the neural crest

39
Q

(+) HMB45

A

Melanosome

40
Q

(+) LCA (Leukocyte Common Antigen) aka CD45

41
Q

best screening marker for lymphoma

A

Leukocyte Common Antigen (aka CD45)

42
Q

(+) CD15, CD30, Ig light and heavy chains

A

Reed-Sternberg

43
Q

used to assess proliferation of tumors

A

Ki-67 (MIB-1) and PCNA (Proliferating Cell Nuclear Antigen)

44
Q

(+) malignant tumors but not specific for malignancy

HISTOPATH (17 decks)

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