Antifungals

Question 1

What is a fungus? What is a fungal infection in a human called? (starts with m)

Answer 1

colorless plan that lacks chlorophyll. Mycotic infection which can range from superficial to systemic

Question 2

What are the two types of Antifungal class drugs based off of their mechanism of action?

Answer 2

Fungicidal or fungistatic

Question 3

What are some examples of why you would use an antifungal?

Answer 3

Superficial infection, tinea pedis, tinea cruris, tinea corporis, onychomycosis (nail), cutaneous, GI, vaginal, deep mycotic (i.e. lungs)

Question 4

What is an adverse effect of topical antifungals?

Answer 4

local reaction (itching or burning)

Question 5

What is an adverse effect of Ketoconazole? A contraindication?

Answer 5

hepatoxicity (discontinue immediately), must have periodic LFTs. Contra: when antacids or histamine antagonists (absorption of Ketoconazole is impaired)

Question 6

Examples of topical antifungals (2) and systemic (3)

Answer 6

T: Clotrimazole, tolnaftate
S: Ketoconazole, Fluconazole (diflucan), Terbinafine (lamisil)