Anticoagulants Flashcards
What is anticoagulation therapy indicated for?
prophylaxis and treatment of venous thromboembolism
What are rivaroxaban and dabigatran contraindicated in?
- renal insufficiency
- when taken in combination with strong inhibitors of CYP3A4 and P-glycoprotein
What are low molecular weight heparins contraindicated in?
- patients with a history of heparin induced thrombocytopenia (HIT)
- should be used with caution in patients with renal dysfunction
What is unfractionated heparin contraindicated in?
patients with a history of heparin induced thrombocytopenia (HIT)
What is warfarin contraindicated in?
- pregnancy
- patients with hemorrhagic tendencies
- blood dyscrasias
- malignant hypertension
- has a number of clinically significant drug interactions which should be assessed prior to initiation of therapy
warfarin (1)
vitamin K antagonist
- Coumadin* (brand name D/C)
Dosage Forms and Strengths
Generic Warfarin (1)
tabs: 1, 2, 2.5, 3, 4, 5, 6, 7.5, 10 mg
heparin (1)
unfractionated heparin
- Heparin LEO**
Dosage Forms and Strengths
Heparin LEO (2)
- IV injection soln: 100 IU/mL (generic not available)
- IV/SC injection soln: 1000 IU/mL (generic not available)
Dosage Forms and Strengths
Generic Heparin (1)
IV/SC injection soln: 1000, 10000 IU/mL
enoxaparin (2)
low molecular weight heparin
- Lovenox
- Lovenox HP
Dosage Forms and Strengths
Lovenox (1)
pre-filled syringes (SC/IV): 30 mg/0.3 mL, 40 mg/0.4 mL, 60 mg/0.6 mL, 80 mg/0.8 mL, 100 mg/mL
Dosage Forms and Strengths
Lovenox HP (1)
pre-filled syringes (SC/IV): 120 mg/0.8 mL, 150 mg/mL
(150 mg/mL)
dalteparin (1)
low molecular weight heparin
- Fragmin
Dosage Forms and Strengths
Fragmin (1)
pre-filled syringes (SC/IV): 2500 IU/0.2 mL, 3500 IU/0.28 mL, 5000 IU/0.2 mL, 7500 IU/0.3 mL, 10,000 IU/0.4 mL, 12,500 IU/0.5 mL, 15,000 IU/0.6 mL, 16,500 IU/0.66 mL, 18,000 IU/0.72 mL, 25,000 IU/1 mL
rivaroxaban (1)
direct factor Xa inhibitor
- Xarelto*
Dosage Forms and Strengths
Xarelto (2)
- tabs: 2.5, 10, 15, 20 mg
- granules: 1 mg/mL (when reconstituted)
apixaban (1)
direct factor Xa inhibitor
- Eliquis*
Dosage Forms and Strengths
Eliquis (1)
tabs: 2.5, 5 mg
edoxaban (1)
direct factor Xa inhibitor
- Lixiana
Dosage Forms and Strengths
Lixiana (1)
tabs: 15, 30, 60 mg
fondaparinux (1)
indirect factor Xa inhibitor
- Arixtra*
Dosage Forms and Strengths
Arixtra (1)
injection soln: 2.5 mg/0.5 mL, 7.5 mg/0.6 mL
dabigatran (1)
direct thrombin inhibitor
- Pradaxa*
Dosage Forms and Strengths
Pradaxa (1)
caps: 75, 110, 150 mg