Anti-emetics

Question 1

Which anti-emetic is used for motion sickness & vestibular disturbances? [1]

Answer 1

Hycosine

Question 2

Describe MoA of hycosine and state use [2]

Answer 2

Hycosine:
* M5 receptor antagonist; prevents Ach action in brainstem or vestibular nuclei

Question 3

Name two drugs given for motion sickness [2]

Answer 3

Diphyenydramine / dramamine
Cyclizine

Question 4

Describe the MoA of:

Diphyenydramine / dramamine [2]
Cyclizine [1]

Answer 4

Diphyenydramine / dramamine: H1 antagonist; M2 antagonist
Cyclizine; H1 antagonist

Question 5

Which drug is used for gastroparesis (delayed gastric emptying)? [1]

Answer 5

Metclopramide

Question 6

What is the MoA of Metclopramide? [2]

Answer 6

D2 receptor antagonist & 5HT4 agonist

Question 7

Name a CB1 receptor agonist [1]

Answer 7

THC

Question 8

What is the MoA of ondansetron and alosetron? [1]
What is the clinical use? [1]

Answer 8

5HT3 agonist; used for chemo and radiotherapy induced emesis

Question 9

Name an atypical antiphyschotic used as an anti-emetic [1]

Answer 9

Olanzapine

Question 10

Name two 5-alpha reductase inhibitors used to treat BPH [2]

Answer 10

Finasteride; Dutasteride

Question 11

Name two alpha-1 antagonists used to treat BPH [2]

Answer 11

Tamulosin; dozazosin

Question 12

Which drugs:

• Relax the detrusor via M3 antagonism?
• Contract the detrusor via M3 agonism?

Answer 12

• Relax the detrusor via M3 antagonism: oxybutynin
• Contract the detrusor via M3 agonism: bethanechol

Question 13

Mirabegron has what therapeutic effect? [1]

Answer 13

Activates B3; causes muscle relaxation