Anaesthetic Drugs Flashcards
Anaesthesia requires 3 things?
Analgesia
Akinesia (paralysis)
Amnesia
Dose of Propofol?
1.5-2.5 mg/kg
Indications of propofol?
Most common
Particularly Maintaining sedation on ITU, total IV anaesthesia and for daycase surgery
Positive effects of propofol? (4)
Rapid onset of anaesthesia
Excellent suppression of airways
Reduces PONV
Rapidly metabolised with little accumulation of metabolites
Negative side effects of propofol? (2)
Drop in HR and BP
Pain on IV injection
Dose of Thiopentone (barbiturate)?
4-5 mg/kg
Indications of thiopentone?
Rapid Sequence Induction (RSI)
Patients with full stomach and increased risk of aspiration
Positive effects of thiopentone?
Faster than propofol
Anti-eplipetic properties & protects the brain
Negative side effects of thiopentone? (5)
Drops BP but rise in HR Rash Bronchospasm Intra-arterial injection: thrombosis and gangrene Little analgesic effects
When is thiopentone contraindicated?
Porphyria
Dose of Ketamine? (Dissociative anaesthesia: anterograde and profound analgesia)
1-1.5 mg/kg
Indications of ketamine?
Used for cases where no major muscle relaxation is required, e.g. burn dressing change
Positive effects of ketamine?
Rise in HR & bronchodilation
Has moderate to strong analgesic properties
Produces little myocardial depression making it a suitable agent for anaesthesia in those who are haemodynamically unstable
Negative side effects of ketamine?
PONV
Emergence phenomenon: vivid dreams, hallucinations
Dose of Etomidate?
0.3 mg/kg
