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Y3 SPRING > AG MED - Hematopoietic Disorders 4 > Flashcards

AG MED - Hematopoietic Disorders 4 Flashcards

1
Q

5 proliferative disorders of the lymphoid and myeloid system

A

Sporadic lymphoma
Adult lymphoma (BLV)
BLADs
Anthrax
Caseous lymphadenitis

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2
Q

How are bovine lymphomas characterized?

A

Frequency of occurrence
Age at onset
Organ involvement
Etiologic agent

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3
Q

What are the four forms of sporadic lymphoma?

A

Calfhood (juvenile)

Thymic (adolescent)

Cutaneous

Multicentric (atypical)

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4
Q

Sporadic Lymphoma - Calfhood

Cause:
Associated with BLV?
Age of onset:
Organ involvement:
Prognosis:

A

Cause unknown, rare
NOT associated with BLV
3-6 months
Generalized lymphadenopathy
Rapidly progressive; death in 2-8 weeks

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5
Q

Sporadic lymphoma - Thymic

Rare or common?
Age at onset:
Associated with BLV?
Organ involvement:
Prognosis:

A

Very rare
Calves 6-24 months old; seen in newborns and up to 4 years
NOT associated with BLV
Brisket edema, bloat, dysphagia
Course of disease is 2-9 weeks at onset
Fatal, usually die from bloat

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6
Q

Sporadic lymphoma - Cutaneous

Associated with BLV?
Age at onset:
History:
Prognosis:

A

NOT associated with BLV
1-3 years of age

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7
Q

This type of sporadic lymphoma is very rare and may be associated with BLV.

Tissues affected:

A

Atypical sporadic lymphoma

Muscle tendons, trachea

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8
Q

Adult lymphoma

Associated with BLV?
Rare or common?
What causes it?

A

Associated with BLV (about 92% of US dairies have + cows)
Most common neoplastic disease of cattle
Oncogenic retrovirus

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9
Q

Bovine leukosis virus

Susceptibility associated with:
Infection or disease more common?
Most cattle that show clinical signs are:
Economic losses?
Transmission:

A

MHC BoLA (bovine leukocyte antigen) type
Infection more common than disease (<5%)
Most cattle that show clinical signs are > 2 years old
Heavy economic losses
Horizontal transmission

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10
Q

Bovine leukosis virus - clinical signs and presentation

A

Hx: loss of condition, drop in milk production
Diarrhea, ataxia, paresis, ketosis (depends on tumor location)
Infertility
Enlarged lymph nodes, exophthalmos
Partial to complete anorexia
Can be 2 years old, usually 4 or older

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11
Q

Bovine Leukosis Virus

PE:
Common tumor site:
GI involvement:
LN involvement:

A

PE: reflects organ system failure from tumor involvement
- cardiac dysrhythmia, tachycardia, tachypnea, hyperpnea

Common tumor site: heart, rumen/reticulum, abomasum, uterus, kidney, spinal cord, retrobulbar space

GI involvement: scant, pasty feces, melena

Peripheral LN and internal iliac LN enlargement

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12
Q

Bovine Leukosis Virus - Clin path

A

CBC unremarkable
microcytic, hypochromic anemia with GI hemorrhage
+/- elevated fibrinogen
Only 30% of cattle develop lymphocytosis

Cytology
FNA of PLN has low sensitivity (41%)
Biopsy of PLN has high sensitivity (around 100%)

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13
Q

Bovine Leukosis Virus - DX

A
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14
Q

Bovine Leukosis Virus

TX:

Control:

A
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15
Q

BLADs definition and epidemiology

A
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16
Q

BLADs pathophysiology

A
17
Q

BLADs clinical signs

A
18
Q

BLADs clin path and DX

A
19
Q

Anthrax etiology

A
20
Q

Anthrax epidemiology

A
21
Q

Anthrax pathogenesis

A
22
Q

Anthrax virulence factors

A

Capsule
Toxic components
- protective antigen (PA)
- lethal factor (LF)
- edema factor (EF)

23
Q

Anthrax clinical signs

A
24
Q

Anthrax DX and DFDX

A
25
Q

Anthrax TX and PX

A
26
Q

Anthrax control and prevention

A
27
Q

Anthrax - Public health concerns

A
28
Q

Caseous lymphadenitis - Etiology

A
29
Q

Caseous lymphadenitis - Epidemiology

A
30
Q

Caseous lymphadenitis - pathophysiology

A
31
Q

Caseous lymphadenitis clinical signs and dfdx

A
32
Q

What disease is this?

A

Caseous lymphadenitis

33
Q

Caseous lymphadenitis - clin path

A
34
Q

Caseous lymphadenitis - DX

A
35
Q

Caseous lymphadenitis - TX

A
36
Q

Caseous lymphadenitis - prevention

A

Y3 SPRING (40 decks)

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