addiction Flashcards
which pathway is really involved with addition
dopamine reward pathway
explain the dopamine reward pathway
1) taking drug stimulates dopamine receptors, leads to an excess od dopamine in the synaptic cleft
=feelings of pleasure and euphoria
2) continuous stimulation of dopamine receptors causes the brain the compensate by DOWNREGULATING/THINNING OUT ACTIVE DOPAMINE RECEPTORS (reduce excess dop. in the brain)
3) natural pleasures not longer pleasurable, need more and continuous drugs (cravings)
in the dopamine reward pathway, how does cocaine binding to a receptor cell in the brain cause addiction
1) taking drug stimulates dopamine receptors, leads to an excess od dopamine in the synaptic cleft
=feelings of pleasure and euphoria
2) continuous stimulation of dopamine receptors causes the brain the compensate by DOWNREGULATING/THINNING OUT ACTIVE DOPAMINE RECEPTORS (reduce excess dop. in the brain)
3) natural pleasures not longer pleasurable, need more and continuous drugs (cravings)
continuous stimulation of dopamine receptors causes the brain the compensate HOW
by DOWNREGULATING/THINNING OUT ACTIVE DOPAMINE RECEPTORS (reduce excess dop. in the brain)
what is the consequence to DOWNREGULATING/THINNING OUT ACTIVE DOPAMINE RECEPTORS (reduce excess dop. in the brain)
natural pleasures no longer feel pleasurable
need more and continuous usage of drugs to feel the same effect
what are the general affects of addiction over time to cortical matter (3)
loss of grey matter in cortex (problem solving, decision making)
loss grey in hippocampus (memory and learning deficits)
loss of grey in cerebellum (movement coordination)
true or false: addiction can affect anyone reguardless of age, gender SES or education
true
what are the risk factors for addiction
genetics
cultural.social/econimic contexts
access to drugs
early life experience
mental helath
true or false: genetics do not play a role in diagnosis
false, they do
true or false: double diagnosis is common in addiction
true
explain double diagnosis
depression can lead to substance abuse
or abuse of a substance can lead to depression
=result in parallel.together due to stressors
what are signs of intoxication
trouble thinking clearly/loss of train of though
slurred speech
blackout
altered gait
paranoid
what are signs of withdrawal
emotional: depressed, anxiety, psychotsis, irritable, isolation
physical: nausea, sweating, HR icnrease
explain the emotional signs of withdrawal
depressed, isolated, irritable, anxious, psychosis
explain the physical signs of withdrawal
HR increase
sweating
nausea