ABX handout

Question 1

• cell wall synthesis inhibitor
• gram + bacteria and limited effect against gram -
• use for mutlidrug resistant bacteria- MRSA and endocarditis

Answer 1

vancomycin

Question 2

• targets cell wall
• INHIBITS mycolic acid synthesis
• first line drug for TB (possibly nocardia as well?)

Answer 2

Isoniazid

Question 3

• targets cell wall
• topical
• used against Gram+ Staph and Group A strep
• **nephortoxic if systemic. not well absorbed from GI

Answer 3

Bacitracin

basset hound in the videos

Question 4

• targets RNA synthesis
• inhibits transcritption
• used against Mycobacterium tuberculosis,M. abium aerobic gram + cocci
• *hepatotoxic

Answer 4

Rifamycins

• examples include rifampin and rifabutin
• riffle in sketchy micro videos*

Question 5

what can we use for tuberculosis?

Answer 5

RIPE
Rifamycin
Isoniazid
Penicillin
E?

Question 6

• target protein synthesis
• translation inhibitor. Blocks 50 s ribosome and inhibits translocation
• anaerobic gram + or gram -
• common dental abs. r factor that methylates rRNA and prevents abs binding to ribosomes

Answer 6

Lincosaminedes
example is lincomycin and clindamycin
**clindamycin can lead to pseudomembranous colitis.
**i’ts not effective against aerobic gram -

Question 7

• protein synthesis
• translation inhibitor. binds 50 s ribosome.
• works against gram + bacteria, other anaerobes not killed at oral admin levels
• can cause GI problems.
• oxotoxic
• use if penicillin allergy

Answer 7

Macrolides
exmamples are Erythromycin, clarithromycin, Azithromycin
**

Question 8

what are the two classes that target protein synthesis by inhibiting translation? (block binding to 50 s ribosome)

Answer 8

Lincosamindes

Macrolides

Question 9

-targets protein synthesis
-RNA polymerase inhibitor for C.Diff only.
3,500 K per treatment

Answer 9

macrocyclics

Question 10

• targets protein syntheisis
• blocks 30 s ribosome
• use against gram + and gram - AEROBES
• Can damage the 8th cranial nerve
• nephrotoxic

Answer 10

Aminoglycosides.
Streptomycin
gentamycin
tobramycin
MY SINS
Toby is aMEAN protein filled gentleman and gives strep to both + and - people who love oxygen.
damages their 8th cranial nerve (auditory?) with all his BS

Question 11

• targets protein synthesis
• blocks 50 s ribosome
• gram + not gram -
• MRSA, VRE

Answer 11

streptogramins.
“Grammy” is POSITIVE,
she looks like she’s 50 and keeps her house “PRISTINE” and eats lots of protein

Question 12

these target protein synthesis

• translation inhibitor for 30s ribosome. stops the tRNA binding
• BROAD SPECTRUM. many gram + and gram -
• exmaples of Rickettsiae, mycoplasma and chlamydia

Answer 12

-tetracyclines
-include doxycyclin and minocycline
-damages developing teeth.
-30 year old protein filled cyclers.
-antacids, dairy, iron, and zinc can reduce the absorption
R factor that alters bacterial cell membrane

Question 13

• new ABX
• target protein synthesis
• blocks tRNA binding to ribosome
• gram + drug resistant infections. MRSA and VRE

Answer 13

Oxaxolidinon

ZYvox and silvextro

Question 14

-protein synthesis
-similar to tetracycline
blocks 30 s ribosome
-broad spectrum- gram pos and more gram - than tetracycline- mycobacterium

Answer 14

glycyclines
-tigecycline
best use for serious resistant staph infections

Question 15

what could you use for serious resistant staph infections?

Answer 15

glycycline

Question 16

• attacks the cell membrane
• binds ERGESTOL in fungal cell membrane
• use for candida and cyrptococcus
• antifungals

Answer 16

POLYENE!!!!

nystatin and Amphotericin

Question 17

• cell membrane
• antiseptic mouthwash
• disrupts the membrane
• works for gram + and gram - bacteria. more effective against gram +
• use as a surgical scrub and as a mouthwash.
• inactivated by some toothpaste

Answer 17

Chlorohexidine

Question 18

-cell membrane
-detergent action
-topical
-gram - (binds to LPS in the gram - wall)
skin, eye infections
-can be neurotoxic, nephrotoxic not GI stable if used internally

Answer 18

Cell membrane ones

*Poly is drinking topical drinks and daping out her lipo”

Question 19

• cell membrane
• disrupts the IONIC concentration gradients
• gram + resistant staph, strep, and enterococci
• give by IV

Answer 19

LIPOPEPTIDE
dap the lip and disrupt the salty damage
use against ESS
Enterococci, staph, strep,

Question 20

DNA synthesis

• STRICT anaerobes and are sensitve and some protozoa
• anaerboes (expcept actinomyces)
• often used to treat C. Diff

Answer 20

NITROIMADAZOLE!!!
metronidazole! lots of weird DNA on the metro. remember the metro!
*antabuse effect with alcohol

Question 21

• works for DNA synthesis
• inhibits the DNA GYRASE-transcription factor
• gram - RODS. NESISSERIA some gram +. not for anaerobes.
• can damage cartilage and growing bone
• DONT use for kids of pregnancy

Answer 21

Quinolones- fluoroquinolones.
-Legionaire’s

Ciprofloxicn.
Quin is a real negative “rod” he goes to the club to check out some FINE DNA, bringing with his flowers and see the girls “gryrasing”
the gyrating action can cause damage to their cartilage and bone. not for kids or preggo women.

Question 22

• only abx for metabolism
• blocks FOLIC acid synthesis- needs folate for DNA
• gram + and gram - actinomyces, Nocardia and chlamydia
• causes hemolytic anemia in patients with g6PD deficiency
• allergy cauer. renal toxicity.

Answer 22

SULFONAMDIES

sulfadizine and trimethoprim

Question 23

what are the B-lactams???

Answer 23

pen V oral or Pen G
methicillin, cloxaccillin, oxacillin
ampilicllin, amoxicillin
Cephalosporin
IMpepenem
-AZtreonam.
CEPHEM!

Question 24

non beta lactam?

Answer 24

Vanco
Bacitracin— TOPICAL! staph and group A step.
Isoniazid -(mycolic)