9 Antivirals + Antiretrovirals

Question 1

antiviral chemotherapy is still in its what period ?

Answer 1

in its infancy

Question 2

Why are viruses more difficult to target than bacteria ?

Answer 2

• they are most vulnerable during reproduction
• but all use host cell organelles and enzymes to do this so,
• antiviral compounds are often as toxic to host as to virus

Question 3

Where do viruses have assumed increasing importance in the setting of in ?

Answer 3

immunosuppression - both drug-induced and AIDS

Question 4

What are an emerging therapeutic option for COVID-19?

Answer 4

antiviral drugs

Question 5

Steps from viral absorption into human cell to viral release ?

Answer 5

1. penetration
2. uncoating
3. early protein synthesis
4. nucleic acid synthesis
5. late protein synthesis and processing
6. packaging and assembly

Question 6

4 mechanisms of action of antiviral drugs ?

Answer 6

• DNA polymerase inhibition
• neuraminidase inhibition
• mRNA synthesis inhibition
• immunomodulators

Question 7

Actions blocked by drug enfuvirtide ?

Answer 7

• viral absorption
• penetration

Question 8

disease treated by enfuvirtide ?

Answer 8

HIV

Question 9

Actions blocked by drug amantadine ?

Answer 9

uncoating

Question 10

disease treated by Amantadine ?

Answer 10

influenza A

Question 11

Actions blocked by drug fomivirsen

Answer 11

early protein synthesis

Question 12

disease treated by fomivirsen

Answer 12

CMV

Question 13

Actions blocked by drug purine/pyrimidine analogues, reverse transcriptase inhibitors ?

Answer 13

nucleic acid synthesis

Question 14

Actions blocked by drug protease inhibtors ?

Answer 14

late protein synthesis and processing

Question 15

Actions blocked by drug rifampin ?

Answer 15

packaging and assembly

Question 16

disease treated by rifampin

Answer 16

Vaccinia

Question 17

disease treated by neuraminidase inhibitors ?

Answer 17

influenza