6. Adrenergic transmission

Question 1

Which are the presynaptic stimulators?

Answer 1

Synthesis:

• Levodopa

Release:

• 4-aminopyridine
• Latrotoxin
• Increase intracellular Ca²⁺
• Presynaptic stimulation of stimulatory receptors
• Presynaptic inhibition of inhibitory receptor (alpha2)
• Reverse transport: tyramine, ephedrine, amphetamin

Reuptake inhibitors:

• Antidepressants
• Cocaine
• …

MAO inhibitors:

• Selegeline
• Tranylcypromine
• Moclobemid
• …

Question 2

Which are the post-synaptic inhibitors?

Answer 2

• Neuronal uptake:
  
  • ​**Reserpine
• Synthesis:
  
  • ​Methyrosine
• Storage:
  
  • Guanethidine, debrisoquin, b**retylium
• Other:
  
  • ​Tetrodotoxin, saxitoxin
  • Clonidine, methyldopa