34. Drugs used in peptic ulcer diseases

Question 1

Which are the groups of antisecretory agents?

Answer 1

• H₂ receptor antagonists
• Proton pump inhibitors
• M₁ receptor antagonists

Question 2

Which are the histamine H₂ receptor antagonists?

Answer 2

• Cimetidine
• Ranitidine
• Nizatidine
• Famotidine

Question 3

Which are the proton pump inhibitors?

Answer 3

• Omeprazol
• Rabeprazol
• Pantoprazol
• Esomeprazol
• Lansoprazol

Question 4

Which are the M₁ muscarinic receptor antagonists?

Answer 4

• Pirenzepine
• Telenzepine

Question 5

Which are the antacids?

Answer 5

• Sodium compounds
  
  • NaHCO₃, sodium nitrate
• Magnesium hydroxide
• Aluminum compounds
  
  • Aluminum hydroxide
  • Aluminum phosphate gel
  • Basic carbonate gel
• Calcium carbonate

Question 6

Which are the drugs that increase the gastric mucosal defences?

Answer 6

• Bismuth chelate
• Sucralfate
• Misoprostol (PG)

Question 7

Which are the antimicrobial treatments in case of H. Pylori peptic ulcer?

Answer 7

• Triple therapy:
  
  • PPI + metronidazole + clarithromycin –> 7 days
  • PPI + amoxicillin + clarithromycin –> 7 days
  • Metronidazole + bismuth salts + tetracycline (or amoxicillin) –> 14 days
• Quadruple therapy:
  
  • ​Bismuth subsalicylate + metronidazole + tetracycline + PPI