23. Drugs used for the treatment of hypertension II: Ca++ -channel blockers and other vasodilators

Question 1

Which are the drug classes for calcium channel blockers?

Answer 1

• Class I: phenylalkilamines (non-selective)
• Class II: Benzothiazepines (non-selective)
• Class III: Dihydropyridines (vasoselective)

Question 2

Which are the drugs of the class I calcium channel blockers?

Answer 2

Class I – Phenylalkilamines (non-selective):

• Verapamil
• Gallopamil

Question 3

Which are the drugs of the class II of calcium channel blockers?

Answer 3

Class II – Benzothiazepines (non-selective):

• Diltiazem

Question 4

Which are the drugs of the class III calcium channel blockers?

Answer 4

Class III – Dihydropyridines (DPH) (vasoselective):

• Short-acting:
  
  • ​Nifedipine
  • Nicardipine
  • Nimodipine
• Intermediate-acting:
  
  • ​Nitrendipine
  • Nisoldipine
  • Felodipine
  • Isradipine
• Long-acting:
  
  • ​Amlodipine
  • Lacidipide
  • Lercanidipine
  • Manidipine

Question 5

What types of vasodilators do we have?

Answer 5

• Direct-acting vasodilators (alpha blockers)
• K⁺-channel stimulants
• D₁ receptor agonists

Question 6

Which are the direct-acting vasodilators (alpha blockers)?

Answer 6

• Hydralazine
• Nitroprusside sodium

Question 7

Which are the K+-channel stimulant vasodilator drugs?

Answer 7

• Minoxidil
• Diazoxide

Question 8

Which are the D1 receptor agonist vasodilator drugs?

Answer 8

• Fenoldopam mesylate