31. Drugs used in coagulation disorders III: Fibrinolytic drugs. Drugs used in bleeding disorders

Question 1

Which are the fibrinolytic drugs?

Answer 1

• Streptokinase
• Staphylokinase
• Urokinase
• Tissue plasminogen activator (tPA)
• Anistreplase
• Alteplase
• Reteplase
• Tenecteplase

Question 2

Which are the groups of drugs used in bleeding disorders?

Answer 2

• Local antihemorrhagic drugs
• Systemic antihemorrhagic drugs

Question 3

Which are the local antihemorrhagic drugs?

Answer 3

• Vasoconstrictors:
  
  • ​E, NE
• Protein denaturating compounds:
  
  • Fe (III)-chloride, K-Al-sulphate, chromoxide, diluted hydrogen peroxide
• Large molecules with large surface
  
  • Collagen, gelatin, fibrin

Question 4

Which are the systemic antihemorrhagic drugs?

Answer 4

Vitamin K:

• Vitamin K1 (food), Vitamin K2 (GI flora)

Fibrinolytic inhibitors:

• Aminocarbonic acid derivatives: Aminocaproic acid, tranexamic acid, …
• Aprotinin

Plasma fractions:

• Cyroprecipitate

Desmopressin