29. Drugs used in coagulation disorders I: Antiplatelet agents

Question 1

Which are the different groups of antiplatelet drugs?

Answer 1

• COX inhibitors
• P2Y₁₂ receptor non-competitive antagonists (anti-aggregation)
• PAR-1 antagonists (thrombin receptor antagonist)
• GP IIb/IIIa receptor antagonists (anti-aggregation)
• PDE inhibitors (impaired PLT function)

Question 2

Which are the COX inhibitors?

Answer 2

Aspirin (Acetylsalicylic acid)

Question 3

Which are the P2Y₁₂ receptor non-competitive antagonists (anti-aggregation)?

Answer 3

Thienopyridines:

• Ticlopidine
• Clopidogrel
• Prasugrel
• Ticagrelor
• Congrelor

Question 4

Which are the PAR-1 antagonists (thrombin receptor antagonist)?

Answer 4

Vorapaxar

Question 5

Which are the GP IIb/IIIa receptor antagonists (anti-aggregation)?

Answer 5

• Abciximab*
• Eptifibatide*
• Tirofiban*

Question 6

Which are the PDE inhibitors (impaired PLT function)?

Answer 6

• Dipyridamole*
• Cilostazol*