5. Cholinergic transmission

Question 1

NMJ Nm receptor blockade?

Answer 1

Atracurium

Question 2

Presynaptic stimulation?

Answer 2

• Stimulation of presynaptic stimulatory receptors
• Inhibition of presynaptic inhibitory receptors
• Higher intracellular Ca²⁺
• 4-aminopyridine (K⁺-channel blocker)
• Latrotoxin (back widow spider venom)

Question 3

Inhibitor of choline/Na⁺ cotransporter in presynaptic nerve endings (Synthesis)?

Answer 3

Hemicholinium

Question 4

Inhibitor of ACh vesicular uptake (storage)?

Answer 4

Vesamicol

Question 5

Inhibitor of Ach vesicle release in the presynaptic nerve endings (release)?

Answer 5

Botulinum toxin

Question 6

Ganglionic blockers?

Answer 6

Competitive (non-depolarizing):

• Tertiary compounds:
  
  • Mecamylamine
  • Trimetaphan
• Quaternary compounds:
  
  • ​Hexamethonium
  • Tetraethylammonium

Non-competitive (non-depolarozing):

• Nicotine