302 Histopathology of the GI tract Flashcards

1
Q

Describe the architecture of the intestine

A

Outside to inwards

-Serosa
-inner circular and outer longitudinal muscularis layer
-Submucosa
-Mucosa
-Lumen

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2
Q

How does acute colitis occur histologically?

A

Not server changes because the disease process hasn’t lasted ling enough to cause too much damage

There will be inflammation

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3
Q

what are some differentials for acute collitis?

A

Acute infection
Drugs
Early stage inflammatory disease

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4
Q

What is the histology of chronic colitis?

A

-Distortion of architecture
-Hyperplasia of cells
-Ulcer-associated lineage indicating attempt to repair
-Fibrosis

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5
Q

Differentials for chronic colitis

A

-Inflammatory bowel disease
drugs
-Microscopic colitis
-Diverticular colitis
-Some infections like syphilis and

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6
Q

What are the features of active ulcerative colitis histologically?

A

-Inflammation in confined to the mucosa
-There will be signs of damage like abscesses and inflammation

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7
Q

How does Crohn’s disease appear histologically?

A

-Cobble stone appearance
-Has areas of normal bowel (patchy skip lesions)
-Fibrosis
-Affects full thickness of the bowel
-Distortion of architecture
-Active inflammation
-Cryptitis and abscesses
-Granulomas (not present in UC)

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8
Q

What is indeterminate colitis?

A

When the features histologically overlap that no diagnosis can be made

Relies heavily on history and clinical presentations

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