3. Cell Injury Flashcards
How do you get a lipid out of the liver?
Put an apoprotein around it
What happens if you can’t get lipids out of the liver?
Fatty liver, hepatomegaly
Where is hemosiderin located?
Macrophages in bone marrow
What is dystrophic calcification?
Abnormal calcification; means you have damaged tissue
What is the most common histologic finding on aortic stenosis?
Dystrophic calcification on bicuspid aortic valve
What is metastatic calcification?
High calcium (or phosphate) in normal tissue
If you can’t see a central area of pallor on an erythrocyte it’s what?
Spherocytosis
What are Mallory bodies?
ubiquinated keratin in alcoholic hepatitis
What 3 cells do you think of for labile cells?
Stem cells - bone marrow, base of intestinal crypts, skin
Most of our parenchymal tissues are what kind of cell?
Stable cells
What is the only muscle that is not a permanent cell?
Smooth muscle - can undergo both hypertrophy and hyperplasia while skeletal muscle can only undergo hypertrophy because they are permanent cells
Which cell phase is variable?
G1 - the others are fixed
What does Rb protein do?
Prevents cell from going G1 to S phase
How do we remove Rb suppression?
Phosphorylation (Cyclin dependent kinase)
How does p53 relate to Rb?
Inhibits cyclin dependent kinase so that Rb won’t be phosphorylated so it prevents cell from going into S phase
