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Goljan > 10. Neoplasia > Flashcards

10. Neoplasia Flashcards

1
Q

What is a hamartoma?

A

Overgrowth of tissue that is normally there in that area

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2
Q

What makes a cell cancerous in terms of mitosis?

A

Atypic mitotic spindle (aneuploid) - has nothing to do with rate

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3
Q

How many doubling times (cell cycles) does it take to get a tumor that is detectable clinically?

A

30

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4
Q

How do carcinomas in general metastasize?

A

Lymphatics first before they become hematogenous- subcapsular sinus of local lymph node

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5
Q

How do sarcomas in general metastasize?

A

Go straight to blood (don’t like going to lymph nodes)

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6
Q

Which thyroid carcinoma likes to spread hematogenously?

A

Follicular

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7
Q

What is analogous in a woman to where the prostate is in a man?

A

Pouch of Douglas

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8
Q

What is the most common metastasis to the liver?

A

Lung > colon

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9
Q

Where would a testicular cancer metastasize to first?

A

Para-aortic lymph nodes

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10
Q

Left supraclavicular node - where is the primary?

A

Stomach cancer (Virchow’s node)

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11
Q

What cancer makes blastic lesions in bone?

A

Prostate

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12
Q

Old man with lower back pain - next step in management?

A

Digital rectal exam - BEFORE PSA

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13
Q

Multiple lesions on gross specimen indicate what?

A

Metastasis!

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14
Q

What is the most common cancer in the brain?

A

Metastasis from lung

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15
Q

What is the most common cancer in the adrenal?

A

Metastasis from lung

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16
Q

Desmin stains what?

A

Muscle

17
Q

Ras and p53 are what kind of mutation?

A

Point mutation

18
Q

What do you treat APML with?

A

Retinoic acid (vitamin A) - matures the blasts

19
Q

What is a major risk factor for bladder cancer?

A

Smoking and aniline dyes

20
Q

What cancer is HIV associated with?

A

Primary CNS lymphoma

21
Q

What is the most common radiation induced cancer?

A

Leukemia (specifically CML)

22
Q

What type of UV light gives you cancer?

A

UV-B

23
Q

What cancer does actinic keratosis predispose to?

A

Squamous cell

Goljan (21 decks)

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