14. Hematology Flashcards

1
Q

Intrinsic vs. extrinsic hemolytic anemia?

A

Intrinsic - something wrong with the RBC that causes it to hemolyze vs. extrinsic - RBC is totally fine and something bad happens to it

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2
Q

Lack of central pallor?

A

Hereditary spherocytosis

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3
Q

What’s the inheritance of hereditary spherocytosis?

A

Autosomal dominant

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4
Q

Why do patients with spherocytosis have splenomegaly?

A

Spleen is what clears these cells

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5
Q

What is the diagnostic test for spherocytosis?

A

Osmotic fragility

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6
Q

What is the treatment for spherocytosis?

A

Splenectomy

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7
Q

At what percentage of HbS do you get sickling?

A

60% - can get spontaneous sickling

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8
Q

Why do we get pain crises in sickle cell?

A

Vasoocclusion from sickle cells –> ischemia –> pain

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9
Q

What happens to the spleen eventually in sickle cell?

A

Autosplenectomy

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10
Q

What does Howell Jolly bodies tell you about the spleen?

A

Spleen isn’t working; splenic macrophages should remove Howell Jolly

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11
Q

When can a kid get their first sickling crisis (dactylitis)?

A

6 - 9 months of age because HbF inhibits sickling (protective for newborns)

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12
Q

What is the cause of osteomyelitis in sickle cell patients?

A

Salmonella (encapsulated)

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13
Q

What drug can we give for sickle cell?

A

Hydroxyurea - promotes HbF synthesis

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14
Q

What are the genetics of G6PD deficiency?

A

X linked recessive

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15
Q

Why do we need G6PD?

A

To regenerate glutathione so we can neutralize peroxide

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16
Q

What 2 drugs should you associate with G6PD hemolysis?

A

Primaquine, dapsone

17
Q

What is the most common autoimmune hemolysis?

A

IgG from SLE

18
Q

Direct vs. indirect Coombs?

A

Direct - IgG/C3b directly on RBC’s vs. Indirect - Ab in the serum

19
Q

Drugs that induce hemolytic anemia?

A

PCN (attaches to RBC), methyldopa (alters Rh antigens on RBC), quinidine (hapten)

20
Q

PCN - rash, type of HSR?

A

I

21
Q

PCN - hemolytic anemia, type of HSR?

A

II

22
Q

Quinidine - hemolytic anemia, type of HSR?

A

III - immune complex with IgM

23
Q

Methyldopa - hemolytic anemia, type of HSR?

A

II

24
Q

What causes leukemoid reaction?

A

Usually infection (overexaggerated response)

25
Q

What cell does EBV infect?

A

B cell (CD 21)