Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Goljan > 12. Hematology > Flashcards

12. Hematology Flashcards

1
Q

Spoon nails/koilonychia and pale conjunctiva?

A

Iron deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the carrier protein for iron?

A

Transferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Transferrin and TIBC relationship?

A

They are the same!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ferritin and TIBC relationship?

A

Inverse/opposite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the shared problem in all microcytic anemias?

A

No hemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What happens in anemia of chronic disease?

A

Body locks iron up in the macrophages in the bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do we differentiate ACD from iron deficiency?

A

Ferritin is increased in ACD vs. decreased in iron deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are sideroblastic anemias?

A

Iron accumulates because of defect in the synthesis of protoporphyrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the rate limiting enzyme in the formation of heme?

A

ALAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the most common cause of sideroblastic anemia?

A

Alcohol - mitochondrial poison

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What vitamin deficiency leads to sideroblastic anemia?

A

B6 (pyridoxine) - associate with Isoniazid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What enzyme does lead poisoning affect?

A

Ferrochelatase (also has a little bit of effect on ALAD but mostly ferrochelatase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Genetic inheritance of thalassemias?

A

Autosomal recessive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Who do we see alpha thalassemia in?

A

Black and Asian

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do we diagnose beta thalassemia?

A

Hgb electrophoresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

4 gene deletion in alpha thalassemia?

A

Hydrops fetalis, formation of tetramer of gamma chains (Hb Barts)

17
Q

What do you form in 3 gene deletion of alpha thalassemia?

A

Tetramer of alpha chains - HbH

18
Q

Why is there an increased rate of choriocarcinomas in Asia?

A

Increased spontaneous abortions from increased rate of hydrops fetalis from alpha thalassemia; the spontaneous abortions are correlated with increased rate of choriocarcinomas

19
Q

How does alpha thalassema with 2 deletions show up on Hgb electrophoresis?

A

It doesn’t since you need alpha chain for all the hemoglobins- they are all decreased so the percentages stay constant. You can only see alpha thalassemia on electrophoresis with 3 gene deletion when you start to form HbH.

20
Q

What is the most common cause of iron deficiency in women under 50?

A

Menorrhagia

21
Q

What is the most common cause of iron deficiency in men under 50?

A

Peptic ulcer disease

22
Q

What is the most common cause of iron deficiency in adults over 50?

A

Colon cancer

23
Q

What is the most common cause of iron deficiency in child under 4?

A

Meckel diverticulum - bleed

Goljan (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions