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Goljan > 11a. Neoplasia > Flashcards

11a. Neoplasia Flashcards

1
Q

What’s the defect in xeroderma pigmentosum?

A

DNA repair

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2
Q

Skin cancer - upper lip?

A

Basal cell

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3
Q

Skin cancer - lower lip?

A

Squamous cell

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4
Q

What is the only bacteria associated with cancer?

A

H pylori

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5
Q

What are the 2 cancers associated with H pylori?

A

Adenocarcinoma and low grade (MALT) lymphoma

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6
Q

What’s the most important prognostic factor in the TNM staging system?

A

M - metastasis (TNM goes in order of importance)

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7
Q

What platelet abnormality do most cancer patients have?

A

Thrombocytosis

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8
Q

What is the most common cause of fever in cancer patient?

A

Gram-negative bacteria (usually nosocomial)

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9
Q

Most common paraneoplastic syndrome?

A

Hypercalcemia

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10
Q

What are 2 mechanisms of hypercalcemia in malignancy?

A
  1. Metastasis to bone

2. PTH-related peptide (this one is paraneoplastic)

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11
Q

Acanthosis nigricans is typically indicative of what cancer?

A

Gastric (acanthosis nigricans is associated with other things but consider gastric adenocarcinoma)

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12
Q

Clubbing is associated with what cancer?

A

Primary lung cancer

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13
Q

Elevated CK and raccoon eyes?

A

Dermatomyositis

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14
Q

Hyponatremia or Cushing’s - cancer?

A

Small cell cancer in the lung

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15
Q

Hypercalcemia or 2 polycythemia vera - cancer?

A

Renal cell carcinoma

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16
Q

Hypocalcemia or Cushing’s - cancer?

A

Medullary carcinoma of the thyroid

17
Q

What 2 tumor markers do you get with testicular cancer?

A

Alpha fetal protein and hCG

18
Q

Alpha fetal protein decreased in pregnancy?

A

Down syndrome

19
Q

Alpha fetal protein increased in pregnancy?

A

Neural tube defect

20
Q

What is a tumor marker for colon cancer?

A

CEA

21
Q

Primary tumor of the brain in kids?

A

Pilocytic astrocytoma (benign)

22
Q

Primary cancer of the brain in kids?

A

Medulloblastoma (malignant)

23
Q

Most common cancer in kids?

A

ALL

24
Q

Most common GYN cancer?

A

Endometrial > ovarian > cervical

25
Q

Why is cervical cancer the least common GYN cancer?

A

Pap smear

26
Q

What are the rates of mortality for GYN cancers?

A

Ovarian > cervical > endometrial

27
Q

What is the only tumor you can vaccinate against?

A

Hepatocellular because you vaccinate against Hep B and you also won’t get Hep D (3 for 1 vaccine!)

Goljan (21 decks)

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