2NS SEM UNIT TEST: pancreatic islets

Question 1

all of the following enzymes are phosphorylated to be functional in the presence of insulin EXCEPT:

Answer 1

Glycogen synthase
Natirang answers for correlation:
glucokinase, hexokinase, phosphorylase kinase

Question 2

presence of amyloid deposits in the islets of Langerhans, mostly affecting the beta cells usually observed in

Answer 2

Adult onset diabetes mellitus

Question 3

The endocrine structures of the pancreas is MOST numerous at the

Answer 3

TAIL

[pinakaleast: HEAD]

Question 4

The pancreatic blood will contain what hormone first?

Answer 4

INSULIN

Question 5

a 45 year old, a diabetes mellitus patient, was seen in the clinic for laboratory work up, which of the following laboratory results will confirm DM diagnosis?

Answer 5

An oral glucose tolerance test (OGTT) 2 hr value of 210 mg/dL and 1 hr value of 220 mg/dL

Question 6

Based on all the functions of the pancreatic polypeptide, it generally

Answer 6

Decreases absorption of nutrients

Question 7

Which of the following hormones causes hyperinsulinemic hyperglycemia?

Answer 7

Growth hormone and cortisol

Question 8

In the presence of insulin, the kidney decreases urine concentration of this electrolyte

Answer 8

sodium

Question 9

Which is NOT usually observe in non-insulin dependent diabetes mellitus (NIDDM) or type 2 DM?

Answer 9

presence of islet cell immunoglobins

Question 10

All of the following is inversely proportional with pancreatic polypeptide activity EXCEPT

Answer 10

Intestinal transit time

Question 11

It is considered a delayed effect of insulin

Answer 11

Lipogenesis

Question 12

Which is a delayed anabolic action of insulin?

Answer 12

Lipid synthesis/Lipogenesis

Question 13

Gestational diabetes mellitus is a condition wherein there is glucose intolerance that is first identified during

Answer 13

PREGNANCY

Question 14

This condition is NOT expected when the beta cells of the islets are stimulated to secrete insulin

Answer 14

Translocation of glucose transporter from the cytoplasm to the cell membrane

Question 15

In the insulin receptor, the tyrosine kinases are present in the

Answer 15

cytoplasmic portion of the beta subunits

Question 16

When INSULIN is exerting its effects on the target cells, which signaling pathway is MOSTLY involved with carbohydrates, fat and protein metabolism?

Answer 16

PHOSPHOTIDYLINOSITOL-3 KINASE PATHWAY

Question 17

In the interactions of hormones (islets of langerhans) somatostatin inhibits the activity of

Answer 17

Beta cells
Alpha cells
F cells

Question 18

The anabolic effects of insulin are usually synergistic with this hormone

Answer 18

Somatotrophic hormone

Question 19

Clinical characteristics of type 2 DM EXCEPT:

Answer 19

Increase insulin sensitivity 
other answers for correlation:
obesity 
hyperglycemia 
late onset with age

Question 20

Action of somatostatin

Answer 20

Inhibits insulin secretion
Decreases GIT absorption
Inhibits glucagon secretion

Question 21

Which of the following promotes hyperglycemia by inhibiting the release of insulin?

Answer 21

epinephrine

Question 22

In the striated muscles, which activity is enhanced in the presence of insulin?

Answer 22

Amino acid uptake

Question 23

Insulin is NOT capable of promoting glucose transport in these cells/tissues

Answer 23

Renal tubular cells
Red blood cells
Small intestinal cells
[EXCEPT IN: breasts, pituitary gland]

Question 24

Before glucose is absorbed,

Answer 24

insulin is already in the blood

Question 25

____ is active in the presence of glucagon

Answer 25

hormone sensitive lipase

Question 26

Insulin release from the pancreatic B cells is thru

Answer 26

exocytosis

Question 27

Which electrolyte is involved in the docking of the insulin containing secretory granules in the beta cells of islets?

Answer 27

CALCIUM`

Question 28

Insulin increases the activities of the following enzymes

Answer 28

glycogen synthase
glucokinase
phosphofructokinase

Question 29

In OGTT of a non-pregnant individual, the oral glucose load is __________

Answer 29

75 grams of glucose dissolved in 300 ml of water

Question 30

Delta: Somatostatin
Epsilon:

Answer 30

Ghrelin