27. Pharmacology V (Cardiovascular/Antibiotics/Antifungals Flashcards
Pacemaker of the heart
- loc: superior portion of Right atrium
- crista terminalis
Sinoatrial node
BQ: Which of the ffg is an anti arrythmic drug?
Quinidine
BQ: Antiarrythmic drug: ⬇️BP ⬆️💜fxn
Digitalis
❤️”digdigdig”
BQ: Betablocker + antiarrythmic
Contraindicated for pxs with ASTHMA
Propanolol
Local anesthetic + antiarrythmic
Lidocaine
BQ: antiseizure + antiarrythmia
Phenytoin
BQ: Antiarrythmic drugs ✨
Quinidine Procainamide Digitalis Propanolol Lidocaine Phenytoin Amiodarone~ Verapamil Adenosine
(Dig-) and (-oside)
Glycosides
BQ: Drugs that increases efficiency of heart to contract
✅for CHF
Glycosides
BQ: Glycosides slash Diuretics (2)
Digitalis
Digoxin
Increases urine formation and urine elimination
✅For EDEMA - to reduce fluid
✅Hypertension - ⬇️BV by urination to ⬇️BP
Diuretics
BQ: Doc for “mild hypertension”
Benzothiazides
“mainstay of antihypertensive therapy”
Benzothiazides
BQ: Most potent diuretic drug
Loop diuretics (Furosemide)
Multiple classifications of DIGITALIS
DIGITALIS:
✅Antiarrythmic
✅Glycoside
✅Diuretic
Multiple Classifications of THEOPHYLLINE
THEOPHYLLINE:
✅xanthine
✅stimulant
✅diuretic
Multiple classifications of PROPANOLOL
PROPANOLOL:
✅beta blocker
✅anti arrythmic
✅anti hypertensive
Can reduce blood pressure by reducing blood volume
Diuretics
Ace inhibitors
Captopril
Angiotensin II receptor antagonist
Losartan
Calcium channel blockers
Nifedipine
Verapamil
Antianginal drugs administered inhalationally
Amyl nitrate
3 important chemicals used in formation of anticoagulants
Heparin
Coumarin
Indandiones
Most common vein involved in thromboembolism
Deep femoral vein
Anticoagulants
Aspirin
Heparin
Warfarin (Coumadin) from COUMARIN
Inhibits fxn of Vit K (⬇️Vit k dep CF: 2/7/9/10 = ⬆️clotting time)
Warfarin (Coumadin)
BQ: How to reverse effects of Warfarin resulting to ⬆️clotting time
Increase Vit K (IV)
Inhibits bacterial growth
Bacteriostatic
Kills bacteria by preventing formation of CELL WALL during CELL DIVISION
Bactericidal
Bactericidal antibiotics take effect during what phase of bacterial growth
Exponential or Log phase
Bacteriostatic + Bactericidal = Antagonistic (1+1=0)
Nagtatake effect palang yung bactericidal during cell division
Cell wall synthesis inhibitors (bactericidal)
PCMC ("beta lactams") -Penicillins, cephalosporins,monobactams,carbapenems Glycopeptides - Vancomycin Bacitracin Cycloserine
“Beta lactams” = Bactericidal ❌cellwall
"PCMC" Penicillins Cephalosporins Monobactams Carbapenems
Glycopeptide used for tx of Pseudomembranous colitis(c. Difficile🐛) and for TREATMENT OF “MRSA”
Vancomycin
*metronidazole-pseudomembranous colitis
Drug used to treat “mrsa” (methicillin resistant staph aureus)
Vancomycin
Most numerous microorg in oral cavity
Strep salivarius
Drugs used for GRAM + Strep/staphs oral infections (“Pec”)
Penicillins - narrow spectrum
Erythromycin
Cephalosporins
Antibiotics for oral infections: (pec) are taken for minimum of how many days
Minimum of 5 days
Penicillin resistant staph aureus creates what enzyme against penicillin
Penicillinase or “Beta lactamase”
Classified as “penicillinase-resistant penicillin”
Methicillin
Tx for mrsa
Vancomycin (Iv)
Last resort of antibiotics
Colistin
Cell wall synthesis inhibitors=Bactericidal
- PCMC (Penicillins, Cephalosporins, Monobactams, Carbapenems)
- Glycopeptides
- Bacitracin
- cycloserine
Only protein synthesis inhibitor that is BACTERICIDAL
Aminoglycosides
streptomycin, gentamycin, tobramycin, neomycin
Blocks 30s ribosomal unit
Aminoglycosides
Tetracycline family
- Tetracycline/Doxycycline/Minocycline
BQ: Antibiotic with “broadest spectrum”
Tetracycline
Adverse effect of Aminoglycosides
Ototoxic (streptomycin)
Drugs that are HEPATOTOXIC (“HART”)
Acetaminophen
Rifampicin
Tetracycline
BQ: Drugs assoc with PHOTOSENSITIVITY (“TIN”)
Tetracycline
Ibuprofen
Naproxen
Tooth discoloration caused by tetracyclines. Until what age?
8y/o
Drug assoc with resistance and superinfections
Tetracycline
Macrolides (“MACE”)
Azithromycin
Clarithromycin
Erythromycin
Blocks 50s ribosomal unit
Macrolides
- (Azithro, Clarithro, Erythromycin)
Clindamycin
Chloramphenicol
Most common Side effect of Macrolides:
Gastrointestinal irritation
1st Macrolide; has the most severe side effect
Erythromycin
Bacteriostatic; but once you increased the dose - it becomes BACTERICIDAL
Clindamycin
Used when allergic to penicillin
Clindamycin
2nd option: erythromycin
Side effect/dse assoc with Clindamycin
Pseudomembranous colitis
Blocks 50s ribosomal unit; Last resort due to high toxicity and adverse effects
Chloramphenicol
Hemolytic anemia and “GRAY BABY SYNDROME” 👶🏻
Chloramphenicol
Protein synthesis inhibitors (bacteriostatic)
AT30/MCC50
- (bactericidal:aminoglycosides)
Lincomycin
Biosynthetic pathway inhibitor; mimics PABA
Sulfonamides
BQ: Brand name of Co-trimoxazole
Bactrim
BQ: 2 drugs combined = Co-trimoxazole / Bactrim
Sulfamethoxazole
Trimethoprim
BQ: Quinolones are derived from?
Quinolines
BQ: Which of the ffg is an anti arrythmic drug? *
Quinidine (anti arrythmic)
BQ: Most allergenic drug
Penicillin
BQ: penicillin administered parenterally
Pen G (inGection)
1st penicillins
Pen G
Natural penicillins
Pen G
Pen VK
Benzylpenicillin: G or VK?
Pen G
Phenoxybemethyl penicillin: G or VK?
Pen VK
BQ: Penicillin administered orally?
Pen VK (“vivig”)
Extended penicillins - “Aminopenicillins”
Aminopenicillins:
- amoxicillin
- ampicillin
BQ: most commonly used when giving oral prophylactic antibiotics to prevent ENDOCARDITIS (strep viridans)
Amoxicillin
BQ: prophylactic dosage of amoxicillin
Adults:
Pedo:
Adult - 2g / 2,000mg
Child - 50mg/kg
30-60mins prior to invasive procedure
Drug given if allergic sa Penicillin
Clindamycin
Prophylactic Dosage of Clindamycin
Adults:
Pedo:
Adults: 600mg
Child: 20mg/kg
“Antipseudomonas penicillins”
broad spectrum
Piperacillin
Ticarcillin
Penicillinase resistant penicillins (“antistaphylococcal penicillins”)
Methicillin ✅ Nafcillin Cloxacillin Oxacillim Dicloxacillin
Doc for upper respiratory tract infections
Co-amoxiclav (Augmentin)
- amox + clavulanic acid
Microorg usually assoc with Pus and Resistance
Staphylococcus
Prsa/mrsa
BQ: has “cross allergenicity” to penicillins
Cephalosporins
A broad spectrum antibiotic with FOUR generations
Cephalosporins
BQ: Which of the ffg is true about CEPHALOSPORINS?
Remember: 1st gen: gram + & narrower — —- 4th gen: gram - & broader
Example:
❌ 1st gen (-) ; 4th gen (+)
(-ams)
Monobactams
(-ems)
Carbapenems
Beta lactam with broadest spectrum
Carbapenems
BQ: Drugs effective for Gram positive streps and staphs
PEC
Penicillins
Erythromycin
Cephalosporins
Drugs that have slight resistance to Penicillinase
Cephalosporins
Monobactams
Carbapenems
BQ: topical antibiotics (except):
Bacitracin
Polymyxin B
Neomycin
BQ: which of the ffg drug is given parenteral? *
Ampicillin
BQ: Antifungal that is given IV
Amphotericin B
DOC for oral candidiasis (“moniliasis/thrush”)
Nystatin
(-azole)
Antifungals
(-prazole)
PPI: Omeprazole-Gerd
Most potent antifungal drug
Griseofulvin