13. Nervous System (Injuries/Disorders) Flashcards
Least severe nerve injury: Damage of MYELIN SHEATH resulting to temporary loss of nerve function but reversible
Neuropraxia
Nerve injuries that are capable of regeneration
Neuropraxia
Axonotmesis
Nerve injury WITHOUT wallerian degeneration
Neuropraxia
Nerve injuries WITH wallerian degeneration
Axonotmesis
Neurotmesis
Nerve injury NOT CAPABLE of regenerating (rate: nerve grafts can be used)
Neurotmesis
Damage of AXON and MYELIN SHEATH (Naputol ung axon)
Axonotmesis
Most severe nerve injury
Damage of EPI/PERI/ENDONEURIUM
Neurotmesis
What part of the nerve is degenerated in axonotmesis
Distal segment of axon
Outermost layer of axon
Epineurium
Middle layer of axon
Perineurium
Innermost layer of axon
Endoneurium
Average nerve regeneration
1.0-1.5mm/day
Beq: Average nerve regeneration for 30days
30-45mm/day
301 /// 301.5
Boards: 28mm/30days!
PNS neuroglia that provides structural support
Satellite cells
Largest nerve fiber
A fibers
Smallest nerve fiber
C fibers
Nerve fiber with FASTEST nerve conduction
A fibers
Nerve fiber with SLOWEST nerve conduction
C fibers
Myelinated nerve fibers
A and B fibers
Unmyelinated nerve fiber
C fibers
Specific nerve fiber for touch
A beta fibers
Specific nerve fiber for FAST SHARP PAIN
A Delta (“Dolor=Pain”)
Nerve fibers for sensations from Visceral organs
B fibers (Visceral - “B” “V”)
Nerve fibers for SLOW DULL PAIN
C fibers (“C-low”)
Neurotransmitters that CREATES action potential
- allows entry of CA+IONS (Na+)
Excitatory nt
Neurotransmitters that PREVENT action potential
- allows entry of ANIONS (Cl-)
Inhibitory nt
What type of nt is DOPAMINE (mood)
Excitatory nt 😊
What type of nt is DOPAMINE (in MOTOR neurons)
Inhibitory nt
5 examples of EXCITATORY nt
GADoNS Glutamate Ach Dopamine (mood) Norepi Serotonin
4 examples of inhibitory nt
Melatonin
Dopamine (motor)
Glycine
GABA
Most common inhibitory neurotransmitter
GABA
Gamma-amino butyric acid
3 ways for REMOVAL or inactivation of Neurotransmitters in the synaptic cleft
Diffusion
Enzymatic degradation
Reuptake by cells
Breaks down Ach
Acetylcholinesterase
Breaks down monoamines
Catecholamine enzymes
Excessive DOPAMINE and serotonin
Schizophrenia
Doc for schizophrenia
Antipsychotic drugs
Side effect of antipsychotic drugs
Tardive dyskinesia
Reduced DOPAMINE
Parkinson’s Disease
4 drugs in tx parkinson’s
Levadopa
Stimulants (DoNES)
Anticholinergic
Mao-I
Abnormal synchronous electrical discharge from neurons; Most common cause is brain damage at birth
Epilepsy
Abnormal firing of neurons = tremors
Seizure
Absence seizure (no tremors)
Petitmal seizure
Doc for epilepsy
Antiepileptic drugs:
Benzodiazepines - Diazepam : Valium
Diphenylhydantoin - phenytoin : Dilantin sodium
Side effect of phenytoin or dilantin sodium
Gingival hyperplasia
Drugs that alters reaction to local irritants like Calculus resulting to GINGIVAL HYPERPLASIA
Phenytoin/Dilantin sodium
Hormonal pills
Nifedipine(amlodipine:hypertnsn)
Cyclosporins
Treatment for Gingival hyperplasia
Gingivectomy
Malignant tumor of the adrenal glands
Neuroblastoma
Destruction of myelin sheath in the CNS
Multiple sclerosis
Destruction of myelin sheath in PNS
Guillan-Bare syndrome (GBS-PNS)
Degeneration of motor neurons in the brain and spinal cord resulting to muscle weakness and atrophy
- Motor neurons : movt = Paralysis
Amyotrophic lateral sclerosis (ALS)
Other name of ALS
Lou Gehrig’s Disease
COD of pxs with ALS or Lou Gehrig’s disease
Respiratory depression
- bec of degeneration of motor neurons in Diaphragm
Loss of hearing due to aging
“Hearing after 40s”
Presbycusis
Loss of visual acuity due to aging
- “Vision after 40s”)
Presbyopia
Reduced salivary production / reduced amylase
Aptyalia
Dry mouth
Xerostomia
Difficulty in swallowing
Dysphagia
Absence of muscle coordination
Ataxia
Inability to speak and comprehend words
Aphasia
Loss of smell sensations
damage to CN I
Anosmia
Blind
- (damage to CN II)
Anopia
Abnormal fixation of eyes
Damaged: CN 3/4/6
Strabismus
Pupil inwards
Esotropia
Pupil outwards
Exotropia
Vision is above the pupil
HyperTROPIA
Vision is below the pupil
HypoTROPIA
Double vision
- (Damaged CN IV)
Diplopia
Sharp pain : damaged CN V
Tic douloureux
Doc for tic douloureux or trigeminal neuralgia
Carbamazepine (Tegretol)
Damage to CN VII
Bell’s palsy
Wandering eye
- (damaged: CN 3/4/6/8)
Nystagmus
Dizziness; rotating environment
- (damaged to CN VIII)
Vertigo
Ringing of the ear
- (damaged CN VIII)
Tinnitus
Loss of taste sensation
Damage to CN 7/9/10
Ageusia
Drooping eyelid
Ptosis
Downward and retraction of tongue; may cause airway obstruction
Glossoptosis
Difficulty in speaking
Dysarthria
Tachycardia and dysphagia - damage in what CN?
Cn X
Sternocleidomastoid and trapezius paralysis - damage to what nerve?
Damage to CN XI