21. Microbio: Viral/Fungal/Parasitic Pathology Flashcards
Virus can either be
RNA or DNA but NEVER BOTH!
BQ: Virus common to produce latent (recurrence) infections
Herpes viruses
Herpes virus in Oral cavity (dormant in CN V)
HSV Type I
Primary lesion of HSV Type 1
- small mouth ulcerations associated with fever and malaise
Primary herpetic gingivostomatitis
Secondary lesion of HSV Type 1
- lip ulcerations
Herpes labialis
Type of HSV in genitals (dormant in sacral ganglia)
HSV Type 2 - genital: Sacral ganglia
DNA virus dormant in salivary glands
Cytomegalovirus
Dna virus assoc with “BIHHN”
EBV: Epstein Barr Virus “BIHHN” - Burkitts lymphoma - Infectious mononucleosis 💋 - Hodgkin’s lymphoma - Hairy leukoplakia - Nasopharyngeal carcinoma
“non hodgkin’s lymphoma”
- B lymphocyte malignancy
- Has african endemic variant
Burkitt’s lymphoma
(Kissing’s/mono) transferred through saliva. Caused by EBV and Cytomegalovirus
Infectious mononucleosis
Histologic of Hodgkin’s lymphoma
Reed-sternberg cells (enlarged lymphocytes)
White patches on tongue caused by EBV
Hairy leukoplakia
Carcinoma on the nasopharynx
Nasopharyngeal carcinoma
Virus dormant in the posterior root (sensory) ganglia of spinal cord
Varicella zoster virus
Causative agent of Chicken pox
Varicella zoster
Causative agent of Shingles
Herpes zoster
Recurrent chicken pox
Shingles
Chicken pox is commonly assoc with what disease that is characterized with HEPATOTOXICITY and ENCEPHALITIS
Reye’s syndrome
- hepatotoxicity and encephalitis
Lesions in shingles typically follow a ___ which is an area of skin that is mainly supplied by a single spinal nerve
Shingles : DERMATOME
Lesions are localized
Causative agent of Kaposi’s sarcoma
HHV 8: Human herpes virus 8
One of the LARGEST and most complex vieus known but it is completely irradicated
Small pox / Variola
Histologic inclusion bodies of Smallpox/Variola
Guarneri Bodies
Virus that causes pharyngitis, pneumonia and conjunctivitis
Adenovirus
Causes warts and cervical cancer
HPV: Human papilloma virus
Smallest double stranded DNA virus
Hepadnavirus (Hepa B virus)
Causes Hepatitis B
Hepadnavirus (Hepa B virus)
BQ: Incubation period of Hepa B
6 to 8 weeks
BQ: Only hepatitis virus that has DNA genome
Hepadnavirus (Hepa B virus)
BQ: Most difficult microorg to be eliminated in sterilization (2)
**Hepadnavirus (Hepa B virus) - most difficult to!!!
Pero difficult din yung SPORES (bacillus/clostridium)
Enzyme used by Hepadnavirus/Hepa B virus to allow viral replication
Reverse transcriptase
Vira antigen of Hepa B detected in serum during blood test
HBsAg
2 viral antigens of Hepatitis B
HBsAg - Hepa B surface antigen(more impt bec it can be detected in blood test)
HBcAg - Hepa B core antigen
Antibodies for Hepa B
HBsAb
Picornavirus
Hepa A
HepaDNAvirus
Hepa B
Flavivirus
Hepa C
Delta virus
Hepa D
–bago ka mag ka Hepa D dapat ngka hepa B ka muna
Calicivirus
Hepa E
Type of Hepatitis: Enteral (Fecal-oral) mode of transmission
Hepa A and E
Type of hepatitis with Parenteral and Sexual contact mode of transmission
Hepa B/C/D
RNA virus that causes rabies
Rabies virus - (Rhabdoviridae)
Histologic intracytoplasmic bodies of Rabies virus
Negri bodies
Transmission of rabies virus
Rabid animal bite
Disease caused by Poliovirus
Transmission: Fecal - oral
Affects anterior horn of spinal cord - MOTOR (“SPAM”)
Poliomyelitis - Poliovirus
Muscle paralysis: ant horn affected=motor
Causative agent of common cold
Rhinovirus
Coxsackie A causes ulcers in the posterior of oral cavity which is called
Herpangina - Coxsackie A
2 Diseases assoc with Coxsackie A
Herpangina
Hand foor mouth disease
BQ: Causes FLU and Adult Viral Pneumonia
Influenza virus
Influenza virus contains spikes (2)
*neuramidase and hemagglutinin
Treatment for Flu and Adult viral pneumonia
Amantadine and Rimantidine
To prevent viral multiplication
BQ: Dse associated with koplik spots
Rubeola or measles
1 L = 1 word
Whitish lesion surrounded by bluish red areola assoc with Rubeola
Koplik spots
Causative agent of Rubeola
Paramyxovirus
BQ: Causes Rubella or german measles
Togavirus
Gumraduate ung german
“German measles”
Rubella
2 L = 2 words
Complication assoc with Rubella or german measles
Congenital defects: deafness/microcephaly
BQ: paRRMyxoviruses
Rubeola
Respiratory synctial virus
Mumps
Causes viral pneumonia in INFANTS
Respiratory Synctial virus
Causes viral pneumonia in ADULTS
Influenza virus (orthomyxovirus)
Swelling of parotid gland (parotitis)
Mumps
2 Complications of mumps
Orchitis - inflammation of testes (assoc with sterility: must occur before or after pubertal; if during HIGH RISK)
Oophoritis - inflammation of ovaries
“Live attenuated” vaccine for MMR
MMR vaccine
Type of Vaccine used for tx of MMR using DEAD virus
Salk vaccine (sinalksalk 🔪)
Type of vaccine used for tx of MMR using alive but WEAKENED virus
Sabin vaccine - (save)
Most common cause of GASTROENTERITIS in children <2y/o
Rotavirus (from Reoviruses)
5 types of Flavivirus
Dengue virus Yellow fever Zika virus West nile virus Hepatitis C virus
Attacks bone marrow cells resulting to LEUKOPENIA (⬇️Wbc) and THROMBOCYTOPENIA (⬇️platelets)
Dengue virus
Capillary fragility test
Tourniquet test (Positive= petechiae)
Virus that attacks lover resulting to YELLOWing of the skin
Yellow fever
Histologic inclusion bodies seen in YELLOW fever
Councilman bodies
Assoc with Guillian-Barre syndrome
- causes microcephaly and encephalitis
Zika virus
Degeneration of Myelin sheath in PNS
Guillian-Barre syndrome
Degeneration of myelin sheath in CNS
Multiple sclerosis
Type of retrovirus that causes AIDS
Lentivirus
Diseases assoc with Lentivirus or AIDS
Kaposi’s sarcoma
White hairy leukoplakia
Pneumonia
Tests for DX of HIV
ELISA (Enzyme-Linked immunosorbent assay) PCR (polymerase chain reaction) Northern blot Southern blot Western blot
Rna blot test
Northern blot test
Dna blot test
Southern blot
BQ: Detect HIV proteins
Western blot
BQ: Common viral infections with maculopapular rash and blisters
Smallpox
Chickenpox
Measles or rubeola
German measles or rubella
Fluid filled lesion <5mm
Vesicle
Fluid filled lesion >5mm
Bullae
Elevated skin; <1mm
Papule
Elevated skin; >1cm
Nodule
Lesion containing pus
Pustules
Causative agent of MONO
EBV
Due to dermatophytes
Dermatomycosis
Dermatophytes (TME)
TrichoPHYTON
Microsporum
EpidermoPHYTON
Athlete’s foot
Tinea pedis
Tinea in Scalp (head)
Tinea capitis
Jock itch; groin
Tinea cruris (CROIN)
Tinea in nails
Tinea unguium
Tinea in general body surface
Tinea corporis
Painful abscesses in the mouth, lungs, breast, GIT Caused by Actinomyces sp
Actinomycosis
Actinomycetes:gram+ and fungi
Caused by histoplasmosis capsulatum; involves reticuloendothelial system
Histoplasmosis
“valley fever” or “San joaquin fever”
Coccidiodomycosis
Coccidiodomycosis is caused by
Coccidioides immitis
“Thrush or moniliasis”
Fungal infection due to candida albicans
Candidiasis
DOC for candidiasis
Nystatin
Most common cause of mycotic meningitis
Fungal infection in meninges of the brain
Cryptococcosis
Mycotic infection involving lungs, skin, etc
Blastomycosis
Amoebiasis is caused by
Entamoeba histolytica
Produces “bloody diarrhea”
Amoebiasis
- (amoeba penetrates large intestine resulting to bleeding)
BQ: Treatment for Amoebiasis for anaerobes and protozoa
Co-trimoxazole (Bactrim*: boards)
Doc for amoebiasis for anaerobes only
Metronidazole
Caused by plasmodium
Vector: female anopheles mosquito
Attacks LIVER
Malaria
Tx for MALARIA (3)
Quinine
Quinolone
Tetracyclines
Caused by Toxoplasma gondii (raw/uncooked food)
Toxoplasmosis
Causative agent for Pneumocytosis
Pneumocystis carinii or jirovecii
pneumonia
Inflammation of vagina, prostate or urethra caused by trichomonas vaginalis
Trichomoniasis
BQ: painful ulcers in mouth “px doesn’t want to eat” or “difficulty in eating”
Primary herpetic gingivostomatitis
2 Viruses assoc with “mono” or infectious mononucleosis or kissing’s disease
Cytomegalovirus
EBV - more common!!!! Choose this sa boards
Aka “kissing’s disease”
Infectious MONOnucleosis
- because cytomegalovirus is transmitted thru saliva
Histologic appearance of CytoMEGAlovirus
Owl’s eye (Mega= malaki)
5 diseases assoc with EBV
Burkitts lymphoma Inf mono Hodgkins lymphoma Hairy leukoplakia Nasopharyngeal carcinoma
BQ: lymphoma with “AFRICAN VARIANT”
Burkitt’s lymphoma
Histologic appearance of Burkitt’s lymphomA
Starry sky
Differential diagnosis of hairy leukoplakia
Candidiasis
White mucous patches of secondary syphilis
Herpesviridae family 5
Herpes simplex virus Cytomegalovirus Epstein barr virus Varicella zoster virus Human herpes virus 8
Recurrent lesion of varicella zoster virus
Shingles
Complication associated with SHINGLES
Permanent paresthesia (sensory:posterior root)
Formula to have Reye’s syndrome
Must be a CHILD
Any viral infection
Aspirin (anticoagulant to; pero anti pyretic din ito lng gngmt dati pag may fever)
Malignancy of immunocompromised patients
Kaposi’s sarcoma
Viruses (2) assoc with kaposi’s sarcoma
HIV and HHV8
“Common wart”
Verruca vulgaris
DNA VIRUSES (BQ:except)
- Herpes viridae family (HSV1/2; cyto; ebv;varicella zoster; HHV8)
- Smallpox/ variola
- Adenovirus
- Human papilloma virus
- Hepadnavirus (hepaB virus)
BQ: Other term for hepatitis B
Serum hepatitis or Dane particle
DNA virus that uses reverse transcriptase during viral replication
Hepa B
RNA virus that uses reverse transcriptase that allows viral replication
HIV
BQ: “Australian antigen”
HBsAg
BQ: Incubation period of Hepa A
2-6weeks
“Bullet shaped virus”
Rabies virus
Verocay bodies
Schwannoma
BQ: ulcers in soft palate and pharynx
Herpangina
BQ: “summer illness”
Herpangina
Family of influenza virus
Orthomyxovirus
BQ: PaRRaMyxoviruses
Rubeola
Respiratory synctial virus
Mumps
Vector of flavivirus
Aedes aegypti
Only flavivirus not transmitted by aedes aegypti
Hepa C (parenteral; sexual contact)
Specie of lentivirus
HIV
BQ: More accurate test in diagnosing HIV
Western blot - go for this sa boards
BQ: “fluid filled lesion” (no size indicated)
Bullae - go for this
BQ: family of HIV
Retrovirus
BQ: Disease assoc with HIV
AIDS
BQ: transmission of HIV
Blood borne; genitals (anal!!)
“Ring worm”
Tinea
BQ: “fungal infection” that resembles TB
Histoplasmosis
2 disease assoc with COIN LESION
Tb
Histoplasmosis
2 diseases that resembles TB
Histoplasmosis
Coccidiodomycosis
Meninges(3)
Dura mater
Arachnoid mater
Pia mater
Temporary storage of CSF
Subarachnoid space
BQ: “pathologic space”
Subdural space
Because it is assoc with TRAUMA, DEATH, INFECTION
BQ: Bactrim generic name (combination of what drugs?)
Co-trimoxazole = sulfamethoxazole + trimethoprim
Vector of Malaria
Female anopheles mosquito
BQ: “anti malarial drugs”
Quinine and Quinolone
BQ: Antimalarial Drug derived from Quinine
Quinolone
BQ: anti arrythmic drug
Quinidine
BEQ: A px w difficulty in eating / ayaw kumain has?
Primary Herpetic Gingivostomatitis
Other name for TYPE II - Genitals
Cold Sores
Other name for Cytomegalovirus
Owls Eye
Molluscum contagiousum is caused by?
POX VIRUS/SMALL POX/VARIOLA
Enlargement of Lymph Nodes:
Infection
Lymphoma
Cystic Lymphoma