2.4 Myeloid

Question 1

AKA Colony forming units

Answer 1

Progenitor cells

Question 2

AKA hemopoietic cytokines

Answer 2

Colony-stimulating factors

Question 3

Source of TPO

Answer 3

Kidney and liver

Question 4

Source of EPO

Answer 4

Kidney and hepatocytes

Question 5

ECM composition of bone marrow

Answer 5

Collagen ype I
Proteoglycans
FIbronectin
Laminin

Question 6

Marrows of newborns

Answer 6

Red bone marrow

Question 7

Marrows of adults

Answer 7

Yellow bone marrow

Question 8

Stimulates production of RBCs in the bone marrow

Answer 8

Hemopoietic growth factor, erythropoietin

Question 9

Stage of erythrocyte maturation where hemoglobin synthesis starts but is not significant enough to change the color of the cytoplasm

Answer 9

Basophilic erythroblast stage

Question 10

Stage in erythrocyte maturation where hemoglobin synthesis is more significant and characterized by lilac color due to presence of both pasiphilia and acidophilia

Answer 10

Polychromatic erythroblast stage

Question 11

Earliest and first recognizable stage of the RBC maturation

Answer 11

Proerythroblast

Question 12

Stage with checkerboard patternStart of synthesis of Hgb

Answer 12

Basophilic erythroblast

Question 13

Stage with lilac color of rbc maturation, more condense nucleus
After this stage, mitotic activity ceases

Answer 13

Polychromatophilic erythroblast

Question 14

RBC stage similar to a mature erythrocyte
Fried egg appearance
Nucleus is found at one side
Acidophillic cytoplasm

Answer 14

Orthochromatophilic erythroblast (normoblast)

Question 15

Most immature recognizable cell in the myeloid series

Answer 15

Myeloblast

Question 16

Stage of granulocyte maturation with basophilic cytpolasm + non-specific azurophilic granules

Answer 16

Promyelocyte

Question 17

Stage of granulocyte maturation with 1st visible sign of differentiation
Specific granules begin
Ovoid nucleus

Answer 17

Myelocyte

Question 18

Stage of granulocyte maturation with deeply indented nucleus, and specific granules

Answer 18

Metamyelocyte

Question 19

Total time taken for a myeloblast to emerge as a mature neutrophil is about ___ days

Answer 19

11 days

Question 20

Platelets are fragments of ___

Answer 20

Megakaryocyte

Question 21

Invaginations of plasma membrane throughout the cytoplasm of the megakaryocyte
Serves as a membrane reservoir for continuous and rapid proplatelet elongation

Answer 21

Demarcation membranes

Question 22

Mitotic compartment of granulocytes

Answer 22

Granulopoietic compartment

Question 23

Granulopoietic compartment which acts as a buffer system; releases neutrophils on demand
Stores neutrophils up to 4 days

Answer 23

Storage compartment

Question 24

Compartment of neutrophils in capillaries and endothelium

Answer 24

Marginating comparment