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ANATOMY > 2.4 Myeloid > Flashcards

2.4 Myeloid Flashcards

1
Q

AKA Colony forming units

A

Progenitor cells

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2
Q

AKA hemopoietic cytokines

A

Colony-stimulating factors

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3
Q

Source of TPO

A

Kidney and liver

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4
Q

Source of EPO

A

Kidney and hepatocytes

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5
Q

ECM composition of bone marrow

A

Collagen ype I
Proteoglycans
FIbronectin
Laminin

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6
Q

Marrows of newborns

A

Red bone marrow

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7
Q

Marrows of adults

A

Yellow bone marrow

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8
Q

Stimulates production of RBCs in the bone marrow

A

Hemopoietic growth factor, erythropoietin

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9
Q

Stage of erythrocyte maturation where hemoglobin synthesis starts but is not significant enough to change the color of the cytoplasm

A

Basophilic erythroblast stage

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10
Q

Stage in erythrocyte maturation where hemoglobin synthesis is more significant and characterized by lilac color due to presence of both pasiphilia and acidophilia

A

Polychromatic erythroblast stage

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11
Q

Earliest and first recognizable stage of the RBC maturation

A

Proerythroblast

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12
Q

Stage with checkerboard patternStart of synthesis of Hgb

A

Basophilic erythroblast

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13
Q

Stage with lilac color of rbc maturation, more condense nucleus
After this stage, mitotic activity ceases

A

Polychromatophilic erythroblast

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14
Q

RBC stage similar to a mature erythrocyte
Fried egg appearance
Nucleus is found at one side
Acidophillic cytoplasm

A

Orthochromatophilic erythroblast (normoblast)

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15
Q

Most immature recognizable cell in the myeloid series

A

Myeloblast

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16
Q

Stage of granulocyte maturation with basophilic cytpolasm + non-specific azurophilic granules

A

Promyelocyte

17
Q

Stage of granulocyte maturation with 1st visible sign of differentiation
Specific granules begin
Ovoid nucleus

A

Myelocyte

18
Q

Stage of granulocyte maturation with deeply indented nucleus, and specific granules

A

Metamyelocyte

19
Q

Total time taken for a myeloblast to emerge as a mature neutrophil is about ___ days

A

11 days

20
Q

Platelets are fragments of ___

A

Megakaryocyte

21
Q

Invaginations of plasma membrane throughout the cytoplasm of the megakaryocyte
Serves as a membrane reservoir for continuous and rapid proplatelet elongation

A

Demarcation membranes

22
Q

Mitotic compartment of granulocytes

A

Granulopoietic compartment

23
Q

Granulopoietic compartment which acts as a buffer system; releases neutrophils on demand
Stores neutrophils up to 4 days

A

Storage compartment

24
Q

Compartment of neutrophils in capillaries and endothelium

A

Marginating comparment

ANATOMY (33 decks)

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