2. Immune response- cells Flashcards
Role of WBCs - neutrophil
Phagocytosis
Role of B cells
Part of antibody Mediated Immune Response
- Produce antibodies
- Antibodies bind and destroy the specific antigen
Name the 5 T-cells involved in the cell mediated Immune response.
- Helper T-cells CD4+
- Cytotoxic CD8+
- Natural Killer t-cells
- Regulatory T-cells (CD8+)
- Memory T-cells
What do helper T-cells do?
Stimulate B cells to make antibodies
What do cytotoxic T-cells do?
Need activation to bind to the antigen and destroy it
What do Natural killer T-cells (innate) do?
Don’t need activation to attack harmful cells
What do Regulatory T-cells (innate) do?
Turn off immune response once infection is destroyed
What do memory T-cells do?
Long lived immunity
Role of WBCs - Macrophage
Phagocytosis
Antigen-presenting cell
Role of WBCs - Dendrite
Antigen- presenting cell
Role of WBCs - Basophil
- Part of inflammatory response
- Release Heparin (prevents blood from clotting too quickly)
- Release Histamine (enlarges blood vessels to improve blood flow and heal)
Role of WBCs - Mast cells
Part of Inflammatory response
Detect ALLERGENS and then ..
Release Histamine (enlarges blood vessels to improve blood flow and heal)
Hypersensitivity
Role of WBCs - Lymphocytes
Turn into B + T cells
Role of WBCs - Eosinophils
Release toxic chemicals
Role of T cells
cell-mediated (does not involve antibodies) immune response
Role of WBCs - monocytes
immune cell made in the bone marrow. Turns into a macrophage or dendritic cells
Role of Hematopoietic stem cells
An immature cell that can develop into any blood cell (WBCs RBCs + platelets)
What are CD8+?
Cytotoxic T cells, Regulatory T-cells
What are CD4+?
Helper T-cells
What are the Innate responses?
present at birth * Phagocytic cells (non-adaptive WBCs) * Not adaptive “
What is the role of the lymphatic system?
The lymphatic system is our body’s ‘sewerage system’.
- Maintains fluid levels in our body tissues by removing all fluids that leak out of our blood vessels
- general and specific immune responses
- absorbing digestive tract fats
- removing cellular waste
Thinking about antibody structure and function. What is Neutralisation?
The ability of antibodies to block the site(s) of bacteria or viruses that they use to enter their target cell.
(Neutralising it at the active site, preventing it from binding)
Thinking about antibody structure and function. What is Opsonisation?
antibody opsonization is a process by which a pathogen is marked for phagocytosis. (Without an opsonin, such as an antibody, the negatively-charged cell walls of the pathogen and phagocyte repel each other)
Thinking about antibody structure and function. What is Complement Fixation?
