12.5 Flashcards
Acetylcholine
Neurotransmitter
Formed from acetic acid
Amino acid neurotransmitters
GABA
Monoamines neurotransmitters
Epinephrine
Norepinephrine
Dopamine
Neuropeptides neurotransmitters
Chains of amino acids
Cholecystokinin
Gas neurotransmitters
NO, CO
Synthesized as needed
Diffuse out of axon terminal
Diffuse into the postsynaptic neuron
Excitatory ACh synapse
- Action potential opens CA2+ channel
- Ca2+ triggers release of ACh
3.ACh diffuses binds to receptors
4.ACh opens NA+ and K+ channels - Entry of Na+ causes depolarization that spreads to trigger zone up to threshold
Inhibitory GABA synapse
- Action potential triggers release of GABA into synaptic cleft
- GABA receptors are Cl channels
- Cl hyperpolarizes postynapic cleft
Excitatory Adrenergic synapse
-binds to G-protein coupled receptors on postynaptic membrane
-activates second messanger system
-slower to respond
To end a signal
-presynaptic cell stops releasing neurotransmitter
-neurotransmitter already in synapse is cleared
Different clearances of neurotransmitter
1.Degradation-enzyme breakdown
2. Reuptake -reabsorbed into axon terminal Diffuse
3. Diffusion-diffuse away from synapse into nearby ECF
Neuromodulators
Chemicals secreted by neurons that have long term modulatory effects on group of neurons
Ex) NO