118 Pyrexial illness Flashcards
What happens to HR when there’s a raise of 1ºC in core body temp
Raise of 15bpm
Which part of the bacteria causes a progenitor response in the host?
LPS of the cell wall
Name an endocrine pyrogen of the immune system
Monocytes
Name 3 pyrogenic cytokines
(4 listed)
- IL-1
- IL-6
- TNFα
- INF
Where in the hypothalamus do the pyrogenic cytokine-receptor interactions happen?
In the pre-optic region
What is the role of PG E2 in the pyrogenic response?
Modifies the responsiveness of the thermosensitive neurones
What do NSAIDs affect the release of in the pyrogenic respose?
PG E2 to reduce fever
What effect does IL-10 have in pyrexia?
Antipyretic - modifies the febrile response by competing with IL-6
Where is CRP produced?
In the liver
What does CRP stimulate?
Opsonin - bacterial cells become more susceptible to phagocytosis - activation of the complement system and recruitment of immune cells
Name the other causes of pyrexia which dont involve the hypothalamus
(4 listed)
- hyperthermia
- drug fever
- malignant hyperthermia
- neuroleptic malignant hyperthermia
Name an autosomal dominant condition which raises the body temp to a dangerous 42ºC?
Malignant hyperthermia
What happens when the intracellular calcium is released abnomally during malignant hyperthermia?
Cardiac arrhythmias
Which 2 drugs can cause neuroleptic malignant hyperthermia?
Haloperidol and chlorpromazine
Name the 4 stages in the manifestation of fever?
- prodronal phase
- chill stage
- flush phase
- defervescence
