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JG Year 1 > 104 Suicide and Self harm > Flashcards

104 Suicide and Self harm Flashcards

1
Q

Which disease is L-DOPA used to treat?

A

Parkinsons

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2
Q

Which OD is N-acetylcystein used to treat?

A

Paracetamol poisoning

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3
Q

What is the MOA of N-acetylcystein?

A
  • Maintains/restores hepatic concentrations of glutathione by producing its precursor - cystein
  • required to inactivate the metabolite of paracetamol which is hepatotoxic.
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4
Q

What dose of paracetamol produces hepatotoxicity?

A

150mg/kg in 1 hour

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5
Q

What investigation is used to determine the degree of paracetamol poisoning?

A

Plasma-paracetamol concentraton

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6
Q

When should initiation of N-acetylcystein commence?

A
  • when plasma paracetamol concentration is above treatment line on the graph
  • when 8-24 hours have elapsed post OD of 150mg/kg
  • after a staggered OD
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7
Q

Which groups are the most likely to commit suicide?

A
  • Women 16-24 yrs
  • Middle aged men
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8
Q

Which OD is this?

  • hypertonia
  • hyperreflexia and extensor plantar response
  • myoclonus
  • myadriasis
  • sinus tachy

What is the antidote

A

TCAs

Use sodium bicarbonate - raises the BP and narrows QRS complex. Affects the protein binding of the drug

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9
Q

Which OD is naloxone used to treat? What is the risk here?

A

Opiate OD. Short half life so risk of re-sedation –> must observe pts.

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10
Q

Which OD is flumazenil used to treat? What is the risk here?

A
  • OD of benzos.
  • Also used as an anti fitting medication so pt may start fitting when reversing OD
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11
Q

Which OD is methionine used to treat?

A

Paracetamol OD - 2nd line

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12
Q

What are the symptoms of CO poisoning?

(5 listed)

A
  • headache
  • nausea
  • vertigo
  • subjective weakness
  • altered level of consciousness
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13
Q

How does CO produce cellular poisoning?

A

Binds to cytochrome A3 and P450 –> inhibits cellular respiration

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14
Q

What investigations should be performed when considering CO poisoning?

A
  • carboxyhaemoglobin measurement
  • ABG
  • ECG
  • U&E
  • CXR

Give 10015 high flow O2 until asymptomatic and SOHb is <10%

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15
Q

What is somatisation?

A

Psychological causes of physical illness

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16
Q

Name the 4 categories of Durkheim’s theory of social integration

A
  1. alturisting
  2. fantalistic
  3. egotistic
  4. anomic
17
Q

Name the 4 methods of decontamination following poisoning (3 aren’t routinely done)

A
  1. forced emesis
  2. gastric lavage
  3. catharsis
  4. activated charcoal
18
Q

What are the 3 methods of advanced elimination when treating poisoning?

A
  1. urine alkalination
  2. haemodialysis
  3. haemoperfusion
19
Q

Which method of advanced elimination is useful in eliminating:

  • Theophyline
  • carbamazepine
A

Haemoperfusion

20
Q

What is the treatment for OD of TCAs?

A

Bicarbonate

21
Q

What is diclobalt used to treat?

A

Cyanide poisoning

22
Q

Which OD show the following:

  • anorexia
  • N&V
  • abdo pain
  • jaundice/encephalopathy
  • renal failure
A

Paracetamol

23
Q

Which OD shows the following:

  • tachycardia
  • hyperthermia
  • delerium
  • agitation
  • myadriasis
A

MDMA

24
Q

Which OD shows the following:

  • coma
  • hypotonia
  • hyperreflexia
  • extensor/absent plantar response
A

Benzo’s

25
Q

Which OD show the following:

  • coma
  • hypertonia
  • hyperreflexia
  • myoclonus
  • myadriasis
  • sinus tachycardia
A

TCAs

26
Q

Which OD shows the following?

  • coma
  • vomit
  • miosis
  • reduced RR
A

Opiate

27
Q

Which OD shows the following:

  • N&V
  • tinnitus
  • deafness
  • sweating
  • hyperventilation
  • vasodilation
  • metabolic acidosis
A

Salicylates

28
Q

Which poisoning shows the following:

  • headache
  • nausea
  • dizziness
  • weakness
A

Carbon monoxide

29
Q

What is the MOA of sodium thiosulphate in the treatment of cyanide poisoning?

A

Produces methaemoglobin which binds to cyanide

30
Q

What are the SE of diclobalt in the treatment of cyanide poisoning?

A
  • facial oedema
  • VT
  • anaphylaxis
31
Q

What does cyanide bind to intracellularly to exert its toxic effects?

A

Cytochome A3 –> no cellular respiration

JG Year 1 (27 decks)

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