1: Brain Injury Overview Flashcards
Primary injury defines and determines
Mechanism of primary injury
The primary injury defines the injury as either traumatic or non-traumatic ;
determine the severity of injury, informs surveillance data, and correlates the injury to an expected long-term outcome
The mechanism of injury is mechanical – for example, neurons damaged from a penetrating injury or from a stroke.
Examples of secondary injury
The release of excitatory amino acids Oxidative free-radical production Release of arachidonic acid metabolites Disruption of neurotransmitters Hypoxia Anemia Metabolic abnormalities Hydrocephalus Intracranial hypertension Hemorrhagic activity
Definition of Mild TBI
Can have either brief or no loss of consciousness and its presentation may demonstrate vomiting, lethargy, dizziness, and inability to recall what just happened
Can result in local neurological deficits that may or may not be transient
Most are not treated in the hospital or emergency department and therefore may not be diagnosed or under-diagnosed in studies
Definition of Moderate TBI
Will be marked by unconsciousness for any period of time up to 24 hours, will have neurological signs of brain trauma, including skull fractures with contusion or bleeding, and may have focal findings on an electroencephalograph (EEG)/computed tomography (CT) scan
Definition of Severe TBI
Marked by a period of loss of consciousness of 24 hours or greater
Risk of multiple TBI following 1st
After 1st TBI, 2nd is 3x more likely ; after 2nd, 3rd is 8x more likely
Rates of TBI 2001-2010
Rates are increasing, deaths are decreasing
TBI and death
TBI contributes to 30% of injury related deaths in US
incidence of mild TBI
75% of TBI are mild
TBI as chronic disease
TBI affects multiple organ systems can cause disease and accelerate disease
TBI as mortality/ morbidity
-Life expectancy is reduced by 7 years Increased risk of death: Aspiration pneumonia – 49X Seizures – 22X Septicemia – 12X Circulatory problems – 29X
neurological conditions associated with TBI
epilepsy, CTE, sleep disturbance, Alzheimer’s
neuroendocrine disorders associated with TBI
Dysfunction of the pituitary gland
Hypothroidism
Growth hormone deficiency/insufficiency
Gonadotropin deficiency
musculoskeletal dysfunctions associated with TBI
spasticity
gait dysfunction
post-injury fractures- at risk for heterotopic ossification
mTBI
aka concussion aka mild TBI
first identified in 16th century
1839 defined
1990’s - focus of increased study due to the prevalence of mTBI in military conflicts
75% of all TBI are mTBI and may be more due to underrepresentation
