Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pulmonology > 08.21 - Histamine (Sweatman) - Questions > Flashcards

08.21 - Histamine (Sweatman) - Questions Flashcards

1
Q

2 major sites of Histamine Biosynthesis

A

Mast Cells, Basophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Enzyme that catalyzes Histamine Biosynthesis

A

L-Histidine Decarboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

3 Notable Activators of Histamine Synthesis and Release

A

GM-CSF, IL-3, Peptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2 Notable inhibitors of Histmaine Synthesis and Release

A

Beta-antagonists; Cromolyn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 Notable Histamine Activating Factors

A

Gastrin, Ca2+, Vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ig isotype that causes Histamine

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cytokine that stimulates B cell to produce IgE

A

IL-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cytokine that stimulates TH1 to release IFN-g

A

IL-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Release of histamine from granule matrix occurs by __ exchange

A

Cation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What percent of Mast Cell Granule does Histamine compose?

A

10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Major actions of H1 receptors

A

SM contraction; Stim of NO formation; Endothelial cell contraction; Incr vascular permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Major actions of H2 receptors

A

Simulation of gastric acid secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Major actions of H3 receptors

A

Inhibition of NT release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mediator of H2 signaling

A

AC –> cAMP –> Decr Ca2+, SIRS, PG –> Extracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mediator of H1 signaling

A

GD –> cGMP –> PG, EDRF –> Extracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Histamine receptors in lung

A

H1 - Bronchoconstrict; H2 - Bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Histamine receptors in heart

A

H1 - Slow AV conduction; H2 - Enhanced constraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Histamine receptors in vasculature

A

H1, H2 - Microvasodilation; H1 - Permeability, Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Histamine receptors in neural tissue

A

H1, H3 - Nerve ending stim, wakefullness and sedation

20
Q

Histamine effects on capillaries

A

No effect

21
Q

Histamine effects on venules

A

H1 - Rapid onset short term dilation (cap permeability); H2 - Slow onset persisent dilation

22
Q

Histamine effects on Veins

A

H1 - Constriction of SM, Dilation of Endo; H2 - Dilation of SM

23
Q

Histamine effects on Arteries

A

H1 - Constriction of SM, Dilation of Endo; H2 - Dilation of SM

24
Q

Histamine effects on Arterioles

A

H1 - Rapid onset short term dilation; H2 - Slow onset persistent dilation

25
Q

Effect of Mast Cells and Basophils on Mucus Glands

A

Diarrhea, Rhinorrhea, Bronchial secretion

26
Q

Effect of Mast Cells/Basophils on Sensory Nerves

A

Itching

27
Q

Advantages of Second Gen Anti-histamines

A

Longer, Fewer doses, Non-sedating, Limited anti-cholinergic

28
Q

3 Notable Side Effects of 1st Gen H1-Antags

A

Impaired cognition, Dystonia, Nasal Congestion

29
Q

1st gen with highest anti-cholinergic

A

Phenothiazines (promethazine)

30
Q

1st gen with highest sedative effect

A

Phenothiazines (promethazine)

31
Q

H1 blocker that acts on alpha-adrenergic

A

Promethazine

32
Q

H1 blockers that act on Cholinergic receptors

A

Diphenhydramine, Promethazine

33
Q

Experimental application of 2nd gen H1 blocker

A

Asthma

34
Q

Side effects of 2nd gen H1 antagonists

A

Mild Cognitive Disturbance; Appetite stimulation

35
Q

For what 2 applications are 1st gens better than 2nd

A

Atopic Dermatitis, Itching Dermatosis

36
Q

For what 4 applications are only 1st gens effective (over 2nd)

A

Motion sickness, Antiemetic, Appetite Stimulation, Insomia

37
Q

H4 receptor function

A

Hematopoeitic Cells: Mast Cell-dependent recruitment of neutrophils during inflammation

38
Q

Locations of H1 receptors other than SM and Endothelium

A

Adrenal Medulla, Heart, CNS

39
Q

Locations of H3 receptors

A

CNS, PNS, Endothelium, Enterochromaffin cells

40
Q

Effect of H1 on Heart

A

Slowed AV conduction

41
Q

Effect of H2 on Heart

A

Enhanced contraction

42
Q

Effect of H1 on Lungs

A

Bronchoconstriction

43
Q

Effect of H2 on Lungs

A

Bronchodilation

44
Q

Effect of H1 on Neural Tissue

A

Nerve ending stimulation; Wakefullness and Sedation

45
Q

Effect of H1 on Vasculature

A

Microvasodilation, Cap Permeability, Vasoconstriction

46
Q

1st Gen H1 Antagonists

A

Diphenhydramine, Dimenhydrinate, Promethazine

47
Q

2nd Gen H1 Antagonists

A

Fexofenadine, Cetirizine, Loratidine

Pulmonology (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions