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Pulmonology > 08.20 - Tx of Viral Lung Infection (Sweatman) - Questios > Flashcards

08.20 - Tx of Viral Lung Infection (Sweatman) - Questios Flashcards

1
Q

Which drugs are not metabolized

A

Amantadine, Zanamavir

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2
Q

Hx of Illness that suggest viral vs bacterial cause

A

Slow onset - Viral; Rapid - Bacterial

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3
Q

CRP conc. that suggests viral vs bacterial cause

A

Less than 20mg/L Viral - Greater than 60mg/L Bacterial

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4
Q

Tx of RSV

A

Ribavirin

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5
Q

MOA of Amantadine

A

Viral entry or uncoating

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6
Q

Tx of Enterovirus

A

None

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6
Q

MOA of Zanamivir

A

Release of influenza from infected cell

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7
Q

MOA of Rimantadine

A

Viral entry or uncoating

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7
Q

Neutropenia

A

Acyclovir, Valacyclovir

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9
Q

Tx of Influenza A and B

A

Osetamivir, Zanamivir

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10
Q

Tx of Rhinovirus

A

None

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11
Q

Orthostatic Hypotension

A

Amantadine

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12
Q

Toxicities of Amantadine

A

Neuro, Orthostatic Hypotension

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13
Q

Tx of Influenza A only

A

Amantadine, Rimantadine

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14
Q

Clinical profiles that suggest viral vs bacterial cause

A

Viral - Rhinitis, Wheezing; Bacterial - Fever, Tachypnea

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14
Q

Black box warning for Hemolytic Anemia and M/F Teratogenicity

A

Ribavirin

15
Q

Toxicities of Oseltamavir

A

Minimal

15
Q

Toxicities of Rimantadine

A

Minimal

15
Q

Black box warning for renal impairment/toxicity

A

Cidofovir

16
Q

Toxicities of Ribavirin

A

Black box for hemolytic anemia and M/F teratogenicity

18
Q

MOA of Oseltamavir

A

Release of influenza from infected cell

19
Q

CXR findings that suggest viral vs bacterial cause

A

Viral - Sole interstitial infiltrates bilaterally; Bacterial - Lobar alveolar infiltrates

20
Q

Tx of Varicella-Zoster Virus

A

Acyclovir, Valacyclovir

22
Q

MOA of Cidofovir

A

DNA polymerase inhibition

23
Q

MOA of Acyclovir

A

DNA polymerase inhibition

24
Q

WBC Count that suggests viral vs bacterial cause

A

Less than 10x19^9 Viral - Greater than 15x10^9 Bacterial

25
Q

Toxicities of Cidofovir

A

Black box for renal impairment/toxicity

27
Q

Toxicities of Acyclovir

A

Neutropenia, Renal precipitation

28
Q

Which drugs are hepatically metabolized

A

Oseltamavir, Rimantadine, Valacyclovir

29
Q

Tx of Adeno

A

Cidofovir

29
Q

Renal Precipitation

A

Acyclovir, Valacyclovir

30
Q

Tx of Human Metapneumovirus

A

Ribavirin

32
Q

Toxicities of Zanamavir

A

Don’t use with pulmonary disease - Fatal Bronchospasm

34
Q

Tx of Hantavirus

A

Ribavirin

35
Q

Can cause fatal bronchospasm

A

Zanamavir

36
Q

MOA of Ribavirin

A

Viral nucleic acid synthesis

37
Q

MOA of Valacyclovir

A

Pro-drug for acyclovir - DNA polymerase inhibition

38
Q

Which drugs are CYP substrates

A

Oseltamavir(?), Rimantadine(?)

39
Q

Toxicities of Valacyclovir

A

Neutropenia, Renal precipitation

Pulmonology (31 decks)

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