08.20 - Tx of Fungal Lung Infection (Sweatman) - Questions Flashcards
General MOA of Fluorocytosine
Nucleic Acid Synthesis inhibitor
Most common topical azoles
Clotrimazole, Miconazole
Griseofulvin is used to treat
Dermatophytosis
Summary of Ketoconazole
Discouraged - Hepatic, Renal, CYP
GI Toxicity
Itraconazole, Posaconazole, 5-FC
Photopsia Toxicity
Voriconazole
General MOA of Griseofulvin
Mitotic Spindle inhibitor
Important enzyme that azoles work through?
CYP450
Neither Amph B nor Flucytosine undergoes ___ metabolism
Hepatic
Most azoles are eliminated via the __ route, except ___
Hepatic, Fluconazole.
Clinical use of Caspofungin
IV - Aspergillus, Candida
General MOA of Amphotericin B
Punches hole through cell membrane (binds to ergosterol)
Other drug classes beside azoles with concerns over hepatic metabolism
None, maybe Griseofulvin
Which azoles have higest side effect incidence?
Itraconazole, Posaconazole
Pro-arrhythmogenic Azoles
Fluconazole, Posaconazole, Voriconazole
Adverse Effects of Amph B
Infusion-related rxns; Renal Toxicity (anemia)
With the excepton of Fluconazone, azoles are eliminated via what route
Hepatic
2 adverse toxicities of Ketaconazole
Hepatic, Adrenal
Fungal infection causing caseating granuloma
Histo
Summary of Posaconazole
Oral, CYP interactions, Mucormycoses
Infusion-related rxns; Renal Toxicity (anemia)
Amph B
Most significant aspect of Griseofulvin
Drug-drug interactions
How is Amph B administered
IV
Terbinafine Summary
No CYP, Well tolerated
80% of patients receiving oral Amph B experience
Renal Damage
Most common use for Nystatin
Topical only - Candidiasis