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Pulmonology > 08.18 - Pharmacotherapy of Asthma, COPD (Malik) - Questions > Flashcards

08.18 - Pharmacotherapy of Asthma, COPD (Malik) - Questions Flashcards

1
Q

Toxicities of Cromolyns

A

No systemic tox; Irritation of Trachea

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1
Q

Interaction between Glucocorticoids and B2-agonists

A

Glucocorticoids increase transcription of B2AR’s

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1
Q

Omalizumab

A

Anti-IgE mAb

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3
Q

Anti-cholinergics

A

Atropine, Ipratropium

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3
Q

Leukotriene Receptor Blockers

A

Monteleukast, Zafirlukast

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4
Q

Anti-IgE mAb

A

Omalizumab

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4
Q

Zileuton inhibits __ formation by blocking __-

A

Leukotriene formation, FLAP

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5
Q

Systemic effects of Ipratropium

A

No significant

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5
Q

2 Notable adverse effects of Monteleukast

A

Laryngitis/Pharyngitis; Viral infections

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6
Q

Main effect of Beta agonists

A

Incr levels of cAMP

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7
Q

Action of cAMP in B2 agonist effects

A

Stimulates EPAC –> Decr Prolifer; Stim PKA –> Inhibit MLCK –> Relaxation

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7
Q

Interaction between Zileuton and Theophylline

A

CYP1A2

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8
Q

2 ways in which Glucocorticoids decrease inflammatory gene translation

A

Decrease transcription thru CBP; Destabilize mRNA thru TTP

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9
Q

2 main actions of Cromolyn Sodium

A

Inhibit mast cell degranulation; Reduce bronchial hyperactivity

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10
Q

Beta-2-specific: Slow onset, long-acting

A

Salmeterol, Formoterol (use with steroids)

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11
Q

Glucocorticoid with best pharmacokinetics and -dynamics

A

Ciclesonide

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12
Q

When is Theophylline used?

A

Adjuvant to beta-2 agonist and anti-muscarinic

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12
Q

Theophylline serum levesl 5-10 can cause

A

nervousness and insomnia

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12
Q

Zafirlukast and Monteleukast specifically antagonize ___

A

LTD4 receptors

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13
Q

Ligand for beta2 receptors in lung

A

Epinephrine

14
Q

AA is metabolized by __

A

5-LO

15
Q

Which GC has lowest oropharyngeal candidiasis

A

Ciclosenide

16
Q

Interaction between Anti-muscarinics and B2-agonist

A

Anti-muscarinics enhance b2-mediated bronchodilation

17
Q

Leukotriene Synthesis Inhibitor

A

Zileuton

19
Q

G protein that mediates good B2 agonist effects

A

Gs

20
Q

Response to corticosteroids in Asthma vs COPD

A

Good in Asthma, Poor in COPD

21
Q

T/F: Beta-adrinergic receptors in lungs can be de-sensitized

A

False, only in heart

22
Q

2 notable adverse effects of prolonged Oral Corticosteroids

A

Glucose intolerance; Incr BP and weight

23
Q

If you have to use beta-blocker in airway disease, use

A

beta1-selective

25
Q

Adverse effects of Anti-muscarinics

A

Pupillary dilation and cycloplegia

26
Q

LABA’s

A

Salmeterol, Formeterol (use with steroids)

27
Q

3 notable features of Cushingoid Syndrome

A

Muscle weakness; Ruddy complexion; High BP

29
Q

Where is highest density of beta2-adrenergic receptors

A

Lung

30
Q

2 Notable adverse effects of Zafirlukast

A

Liver enzymes elevated; GIT disturbances

32
Q

2 main actions of Theophylline

A

Inhibits PDE; Inhibits Adenosine

33
Q

LABA’s are only used

A

In combo with inhaled steroids

34
Q

Selectivity of Isoproterenol

A

B1 and B2

35
Q

Notable adverse effect of Zileuton

A

Liver enzymes elevated

37
Q

Selectivity of Ephedrine

A

B1 and B2 and some Alpha

38
Q

AA is metabolized by 5-LO, but ___ is what is inhibited by Zileutin

A

FLAP

39
Q

Why not use ACEi’s in airway disease

A

Increased levels of Bradykinin, which causes PGE2-mediated sensitization of nerve endings (cough)

40
Q

What combined tx is indicated for COPD

A

Anti-muscarinic + beta2 agonist

42
Q

3 Minor effects of Beta agonists

A

Inhibit mast cell degran; Inhibit microvascular perm; Promote mucociliary transport

43
Q

LTB4 is a ___ chemoattractant

A

Neutrophil

44
Q

GC action that suppresses TH2 cell cytokine synthesis

A

Competes with GATA-3, which is TF for IL-4, -5, and -13

46
Q

2 Notable Adverse Effects of Omalizumab

A

Serious Allergic Reactions; CV complications

47
Q

Methylxanthines

A

Aminophylline, Theophylline

48
Q

3 main Adverse Effects of B2 agonists

A

Incr HR and Arrythmias; PaCO2 may decrease; CNS toxicities

49
Q

G protein that mediates inflammatory B2 agonist effects

A

Gq

Pulmonology (31 decks)

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